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Type: Journal article
Title: Carbohydrates@MOFs
Author: Astria, E.
Thonhofer, M.
Ricco, R.
Liang, W.
Chemelli, A.
Tarzia, A.
Alt, K.
Hagemeyer, C.E.
Rattenberger, J.
Schroettner, H.
Wrodnigg, T.
Amenitsch, H.
Huang, D.M.
Doonan, C.J.
Falcaro, P.
Citation: Materials horizons, 2019; 6(5):969-977
Publisher: Royal Society of Chemistry
Issue Date: 2019
ISSN: 2051-6347
Statement of
Efwita Astria, Martin Thonhofer … Weibin Liang … David M. Huang, Christian J. Doonan, Paolo Falcaro ... et al.
Abstract: MOFs have demonstrated outstanding properties for the protection and controlled release of different bio-entities, from proteins to living cells. Carbohydrates, as pure molecules or as a component of proteins and cells, perform essential biological functions. Thus, an understanding of the role of carbohydrates in the formation of MOF-based bio-composites will facilitate their application to biotechnology and medicine. Here, we investigate the role of carbohydrate molecular weight and chemical functionalization in the formation of carbohydrate@MOF composites. We find that chemical functionalization, such as carboxylation, that leads to an enhancement of metal cation concentration at the surface of the molecule triggers the rapid self-assembly of the MOF material, zeolitic-imidazolate framework 8 (ZIF-8). Furthermore, we determine the encapsulation efficiency and measure the release properties of the carbohydrate under controlled conditions. Our findings show that MOFs can be used to prepare a new class of biocomposites for the delivery of carbohydrate-based therapeutics.
Rights: Open Access Article. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
DOI: 10.1039/c8mh01611a
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