Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/120531
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Type: Journal article
Title: Cortical inhibition of distinct mechanisms in the dorsolateral prefrontal cortex is related to working memory performance: a TMS-EEG study
Author: Rogasch, N.
Daskalakis, Z.
Fitzgerald, P.
Citation: Cortex, 2015; 64:68-77
Publisher: Elsevier
Issue Date: 2015
ISSN: 0010-9452
1973-8102
Statement of
Responsibility: 
Nigel C. Rogasch, Zafiris J. Daskalakis and Paul B. Fitzgerald
Abstract: Paired-pulse transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) is a method for studying cortical inhibition from the dorsolateral prefrontal cortex (DLPFC). However, little is known about the mechanisms underlying TMS-evoked cortical potentials (TEPs) from this region, let alone inhibition of these components. The aim of this study was to assess cortical inhibition of distinct TEPs and oscillations in the DLPFC using TMS-EEG and to investigate the relationship of these mechanisms to working memory. 30 healthy volunteers received single and paired (interstimulus interval = 100 msec) TMS to the left DLPFC. Variations in long-interval cortical inhibition (LICI) of different TEP peaks (N40, P60, N100) and different TMS-evoked oscillations (alpha, lower beta, upper beta, gamma) were compared between individuals. Variation in N100 slope following single pulse TMS, another putative marker of inhibition, was also compared with LICI of each measure. Finally, these measures were correlated with performance of a working memory task. LICI resulted in significant suppression of all TEP peaks and TMS-evoked oscillations (all p < .05). There were no significant correlations between LICI of different TEP peaks or TMS-evoked oscillations with the exception of P60 and N100. Variation in N100 slope correlated with LICI of N40 and beta oscillations. In addition, LICI of P60 and N100 were differentially correlated with working memory performance. The results suggest that both the LICI paradigm and N100 following single pulse TMS reflect complementary methods for assessing GABAB-mediated cortical inhibition in the DLPFC. Furthermore, these measures demonstrate the importance of prefrontal GABAB-mediated inhibitory control for working memory performance.
Keywords: Transcranial magnetic stimulation; electroencephalography; cortical inhibition; dorsolateral prefrontal cortex; working memory
Rights: © 2014 Elsevier Ltd. All rights reserved.
RMID: 0030120400
DOI: 10.1016/j.cortex.2014.10.003
Grant ID: http://purl.org/au-research/grants/nhmrc/607223
http://purl.org/au-research/grants/nhmrc/1072057
Appears in Collections:Medicine publications

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