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Type: Journal article
Title: Cortical inhibition, excitation, and connectivity in schizophrenia: a review of insights from transcranial magnetic stimulation
Author: Rogasch, N.
Daskalakis, Z.
Fitzgerald, P.
Citation: Schizophrenia Bulletin, 2014; 40(3):685-696
Publisher: Oxford University Press
Issue Date: 2014
ISSN: 0586-7614
Statement of
Nigel C. Rogasch, Zafiris J. Daskalakis, and Paul B. Fitzgerald
Abstract: Schizophrenia (SCZ) is a debilitating mental illness with an elusive pathophysiology. Over the last decade, theories emphasizing cortical dysfunction have received increasing attention to explain the heterogeneous symptoms experienced in SCZ. Transcranial magnetic stimulation (TMS) is a noninvasive form of brain stimulation that is particularly suited to probing the fidelity of specific excitatory and inhibitory neuronal populations in conscious humans. In this study, we review the contribution of TMS in assessing inhibitory and excitatory neuronal populations and their long-range connections in SCZ. In addition, we discuss insights from combined TMS and electroencephalography into the functional consequences of impaired excitation/inhibition on cortical oscillations in SCZ.
Keywords: GABA; cortical inhibition; NMDA; connectivity
Rights: © The Author 2013. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email:
RMID: 0030120408
DOI: 10.1093/schbul/sbt078
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Appears in Collections:Medicine publications

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