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|Title:||Cortical inhibition, excitation, and connectivity in schizophrenia: a review of insights from transcranial magnetic stimulation|
|Citation:||Schizophrenia Bulletin, 2014; 40(3):685-696|
|Publisher:||Oxford University Press|
|Nigel C. Rogasch, Zafiris J. Daskalakis, and Paul B. Fitzgerald|
|Abstract:||Schizophrenia (SCZ) is a debilitating mental illness with an elusive pathophysiology. Over the last decade, theories emphasizing cortical dysfunction have received increasing attention to explain the heterogeneous symptoms experienced in SCZ. Transcranial magnetic stimulation (TMS) is a noninvasive form of brain stimulation that is particularly suited to probing the fidelity of specific excitatory and inhibitory neuronal populations in conscious humans. In this study, we review the contribution of TMS in assessing inhibitory and excitatory neuronal populations and their long-range connections in SCZ. In addition, we discuss insights from combined TMS and electroencephalography into the functional consequences of impaired excitation/inhibition on cortical oscillations in SCZ.|
|Keywords:||GABA; cortical inhibition; NMDA; connectivity|
|Rights:||© The Author 2013. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: firstname.lastname@example.org|
|Appears in Collections:||Medicine publications|
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