Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/120679
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Type: Journal article
Title: Immunogenicity and safety of a quadrivalent meningococcal ACWY-tetanus toxoid conjugate vaccine 6 years after MenC priming as toddlers
Author: Nolan, T.
Booy, R.
Marshall, H.
Richmond, P.
Nissen, M.
Ziegler, J.
Baine, Y.
Traskine, M.
Jastorff, A.
Van der Wielen, M.
Citation: The Pediatric Infectious Disease Journal, 2019; 38(6):643-650
Publisher: Lippincott Williams & Wilkins
Issue Date: 2019
ISSN: 0891-3668
1532-0987
Statement of
Responsibility: 
Terry Nolan, Robert Booy, Helen Marshall, Peter Richmond, Michael Nissen, John Ziegler, Yaela Baine, Magali Traskine, Archana Jastorf, Marie Van der Wielen
Abstract: BACKGROUND:We assessed immunogenicity, antibody persistence and safety of the meningococcal serogroups A, C, W and Y-tetanus toxoid (TT) conjugate vaccine (MenACWY-TT) in children primed as toddlers with MenC vaccine. METHODS:This open, multicenter extension study enrolled children 84-95 months of age who had received one dose of the combined Haemophilus influenzae type b (Hib)-MenC-TT conjugate vaccine (HibMenC group) or Hib-TT and monovalent MenC (MCC)-CRM197 vaccines (Hib+MCC group) at 12-18 months of age, in the primary study. All participants received one dose of MenACWY-TT. We assessed immunogenicity against MenA, MenC, MenW and MenY at 1 month and 2 years postvaccination by serum bactericidal assay using baby rabbit complement (rSBA). Safety and reactogenicity were evaluated. RESULTS:Six years post-MenC vaccination, <20% of children retained rSBA-MenC titers ≥1:8. At 1 month post-MenACWY-TT vaccination, vaccine response rates against all serogroups were high for both groups with ≥97.1% of children having rSBA ≥1:8. Two years postvaccination, ≥63.6% of children retained rSBA-MenA ≥1:8, and ≥87.9% for other serogroups. Geometric mean titers for all serogroups declined at 2 years post-MenACWY-TT vaccination, but remained ≥13 times higher than prevaccination levels. For both groups, pain (≤58.5%), redness (≤51.4%) and fatigue (≤27.0%) were the most frequently reported adverse events. No serious adverse events were reported. CONCLUSIONS:One dose of MenACWY-TT boosts protection against MenC in primed children, is safe and extends protection against MenA, MenW and MenY. Immunogenicity and safety were comparable in infants vaccinated with conjugated vaccine (HibMenC-TT) or the separate vaccines (Hib-TT and MCC-CRM197).
Keywords: Quadrivalent meningococcal vaccine; children; bactericidal activity; persistence; safety
Rights: © 2019 The Author(s). Published by Wolters Kluwer Health, Inc.
RMID: 0030118207
DOI: 10.1097/INF.0000000000002334
Grant ID: http://purl.org/au-research/grants/nhmrc/1084951
Appears in Collections:Paediatrics publications

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