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Type: Journal article
Title: Increased plasma Brain-Derived Neurotrophic Factor (BDNF) levels in females with schizophrenia
Author: Weickert, C.
Lee, C.
Lenroot, R.
Bruggemann, J.
Galletly, C.
Liu, D.
Balzan, R.
Pillai, A.
Buckley, P.
Weickert, T.
Citation: Schizophrenia Research, 2019; 209:212-217
Publisher: Elsevier
Issue Date: 2019
ISSN: 0920-9964
Statement of
Cynthia Shannon Weickert, Cynthia H. Lee, Rhoshel K. Lenroot, Jason Bruggemann, Cherrie Galletly, Dennis Liu, Ryan Balzan, Anilkumar Pillai, Peter Buckley, Thomas W. Weickert
Abstract: Brain-Derived Neurotrophic Factor (BDNF) acts as a critical regulator of synaptogenesis and synaptic plasticity. Sex differences have been demonstrated in many aspects of schizophrenia. This study tested for sex-specific differences in peripheral BDNF levels in people with schizophrenia and healthy controls. We measured circulating plasma BDNF levels in 95 people with schizophrenia and 80 healthy controls. Plasma BDNF levels were significantly elevated in females with schizophrenia compared to males with schizophrenia and to female healthy controls. These results suggest that sex differences in peripheral BDNF levels may contribute to other sex related differences in schizophrenia.
Keywords: BDNF; sex differences; schizophrenia
Rights: Crown Copyright © 2019 Published by Elsevier B.V. All rights reserved.
DOI: 10.1016/j.schres.2019.04.015
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Appears in Collections:Aurora harvest 4
Psychology publications

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