Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: Biomimetic synthetic studies on meroterpenoids from the marine sponge Aka coralliphaga: divergent total syntheses of siphonodictyal B, liphagal and corallidictyals A–D
Author: Kuan, K.K.
Markwell-Heys, A.
Cruickshank, M.C.
Tran, D.P.
Adlington, R.
Baldwin, J.
George, J.
Citation: Bioorganic and Medicinal Chemistry, 2019; 27(12):2449-2465
Publisher: Elsevier
Issue Date: 2019
ISSN: 0968-0896
Statement of
Kevin K.W.Kuan, Adrian W.Markwell-Heys, Michelle C.Cruickshank, Denise P.Tran, Robert M.Adlington, Jack E.Baldwin, Jonathan H.Georgea
Abstract: The marine sponge Aka coralliphaga is a rich source of biologically active and structurally interesting meroterpenoids. Inspired by these natural products, we have used biosynthetic speculation to devise biomimetic syntheses of siphonodictyal B, liphagal and corallidictyals A-D from sclareolide. This work resulted in the development of new cascade reactions in the synthesis of liphagal, the reassignment of the structure of siphonodictyal B, and the realisation that corallidictyals A and B are possibly isolation artefacts.
Keywords: Animals; Porifera; Terpenes; Diterpenes; Sesquiterpenes; Hydroquinones; Biological Products; Biomimetics; Cyclization; Oxidation-Reduction
Rights: © 2019 Published by Elsevier Ltd.
RMID: 0030113327
DOI: 10.1016/j.bmc.2019.02.038
Grant ID:
Appears in Collections:Pharmacology publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.