Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/120883
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Type: Journal article
Title: Biomimetic synthetic studies on meroterpenoids from the marine sponge Aka coralliphaga: divergent total syntheses of siphonodictyal B, liphagal and corallidictyals A–D
Author: Kuan, K.K.
Markwell-Heys, A.
Cruickshank, M.C.
Tran, D.P.
Adlington, R.
Baldwin, J.
George, J.
Citation: Bioorganic and Medicinal Chemistry, 2019; 27(12):2449-2465
Publisher: Elsevier
Issue Date: 2019
ISSN: 0968-0896
1464-3391
Statement of
Responsibility: 
Kevin K.W.Kuan, Adrian W.Markwell-Heys, Michelle C.Cruickshank, Denise P.Tran, Robert M.Adlington, Jack E.Baldwin, Jonathan H.Georgea
Abstract: The marine sponge Aka coralliphaga is a rich source of biologically active and structurally interesting meroterpenoids. Inspired by these natural products, we have used biosynthetic speculation to devise biomimetic syntheses of siphonodictyal B, liphagal and corallidictyals A-D from sclareolide. This work resulted in the development of new cascade reactions in the synthesis of liphagal, the reassignment of the structure of siphonodictyal B, and the realisation that corallidictyals A and B are possibly isolation artefacts.
Keywords: Animals
Porifera
Terpenes
Diterpenes
Sesquiterpenes
Hydroquinones
Biological Products
Biomimetics
Cyclization
Oxidation-Reduction
Rights: © 2019 Published by Elsevier Ltd.
DOI: 10.1016/j.bmc.2019.02.038
Grant ID: http://purl.org/au-research/grants/arc/FT170100437
Appears in Collections:Aurora harvest 8
Pharmacology publications

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