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|Title:||Biomimetic synthetic studies on meroterpenoids from the marine sponge Aka coralliphaga: divergent total syntheses of siphonodictyal B, liphagal and corallidictyals A–D|
|Citation:||Bioorganic and Medicinal Chemistry, 2019; 27(12):2449-2465|
|Kevin K.W.Kuan, Adrian W.Markwell-Heys, Michelle C.Cruickshank, Denise P.Tran, Robert M.Adlington, Jack E.Baldwin, Jonathan H.Georgea|
|Abstract:||The marine sponge Aka coralliphaga is a rich source of biologically active and structurally interesting meroterpenoids. Inspired by these natural products, we have used biosynthetic speculation to devise biomimetic syntheses of siphonodictyal B, liphagal and corallidictyals A-D from sclareolide. This work resulted in the development of new cascade reactions in the synthesis of liphagal, the reassignment of the structure of siphonodictyal B, and the realisation that corallidictyals A and B are possibly isolation artefacts.|
|Keywords:||Animals; Porifera; Terpenes; Diterpenes; Sesquiterpenes; Hydroquinones; Biological Products; Biomimetics; Cyclization; Oxidation-Reduction|
|Rights:||© 2019 Published by Elsevier Ltd.|
|Appears in Collections:||Pharmacology publications|
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