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https://hdl.handle.net/2440/120883
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dc.contributor.author | Kuan, K.K.W. | - |
dc.contributor.author | Markwell-Heys, A.W. | - |
dc.contributor.author | Cruickshank, M.C. | - |
dc.contributor.author | Tran, D.P. | - |
dc.contributor.author | Adlington, R.M. | - |
dc.contributor.author | Baldwin, J.E. | - |
dc.contributor.author | George, J.H. | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Bioorganic and Medicinal Chemistry, 2019; 27(12):2449-2465 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.issn | 1464-3391 | - |
dc.identifier.uri | http://hdl.handle.net/2440/120883 | - |
dc.description.abstract | The marine sponge Aka coralliphaga is a rich source of biologically active and structurally interesting meroterpenoids. Inspired by these natural products, we have used biosynthetic speculation to devise biomimetic syntheses of siphonodictyal B, liphagal and corallidictyals A-D from sclareolide. This work resulted in the development of new cascade reactions in the synthesis of liphagal, the reassignment of the structure of siphonodictyal B, and the realisation that corallidictyals A and B are possibly isolation artefacts. | - |
dc.description.statementofresponsibility | Kevin K.W.Kuan, Adrian W.Markwell-Heys, Michelle C.Cruickshank, Denise P.Tran, Robert M.Adlington, Jack E.Baldwin, Jonathan H.Georgea | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | © 2019 Published by Elsevier Ltd. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.bmc.2019.02.038 | - |
dc.subject | Animals | - |
dc.subject | Porifera | - |
dc.subject | Terpenes | - |
dc.subject | Diterpenes | - |
dc.subject | Sesquiterpenes | - |
dc.subject | Hydroquinones | - |
dc.subject | Biological Products | - |
dc.subject | Biomimetics | - |
dc.subject | Cyclization | - |
dc.subject | Oxidation-Reduction | - |
dc.title | Biomimetic synthetic studies on meroterpenoids from the marine sponge Aka coralliphaga: divergent total syntheses of siphonodictyal B, liphagal and corallidictyals A–D | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.bmc.2019.02.038 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/FT170100437 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | George, J.H. [0000-0002-7330-2160] | - |
Appears in Collections: | Aurora harvest 8 Pharmacology publications |
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