Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/121036
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Type: Journal article
Title: Current state-of-play in spontaneous coronary artery dissection
Author: Franke, K.
Wong, D.
Baumann, A.
Nicholls, S.
Gulati, R.
Psaltis, P.
Citation: Cardiovascular Diagnosis and Therapy, 2019; 9(3):281-298
Publisher: AME Publishing Company
Issue Date: 2019
ISSN: 2223-3652
2223-3660
Statement of
Responsibility: 
Kyle B. Franke, Dennis T. L. Wong, Angus Baumann, Stephen J. Nicholls, Rajiv Gulati, Peter J. Psaltis
Abstract: For over 80 years, spontaneous coronary artery dissection (SCAD) has been recognised as a cause of myocardial infarction. SCAD is described as a non-iatrogenic, non-atherosclerotic coronary artery dissection, resulting in formation of a false lumen or intramural haematoma in the coronary artery wall that compresses the true lumen, often compromising myocardial blood flow. In early literature, the incidence of SCAD in acute coronary syndrome (ACS) was underestimated. Recent advances in awareness and widespread early angiographic investigation in ACS has led to important shifts in our understanding of the prevalence, predisposing causes, natural history, aetiology, clinical and angiographic features, management, and prognosis of SCAD. It is now well understood that SCAD predominantly affects women and is responsible for around 20% of ACS presentations in females below the age of 60. Despite this, SCAD is still often overlooked and misdiagnosed as atherosclerotic disease. Misdiagnosis is multifactorial; with contributing factors including a low clinical index of suspicion, particularly in young females, a lack of clinician familiarity with angiographic variants, and limitations of angiography. Although increasing evidence suggests that optimal management is distinct from atherosclerotic coronary artery disease, many questions remain unanswered regarding the pathogenesis and optimal treatment of SCAD, heralding prospective research to answer these questions. This review aims to give a current clinical perspective on SCAD and highlight the importance of familiarity and vigilance with this condition when diagnosing and treating ACS.
Keywords: Acute coronary syndrome (ACS); myocardial infarction; non-atherosclerotic coronary artery disease; spontaneous coronary artery dissection (SCAD)
Rights: © Cardiovascular Diagnosis and Therapy. All rights reserved.
RMID: 0030127735
DOI: 10.21037/cdt.2019.04.03
Grant ID: http://purl.org/au-research/grants/nhmrc/1161506
Appears in Collections:Medicine publications

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