Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/121176
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: The contrasting phylodynamics of human influenza B viruses
Author: Vijaykrishna, D.
Holmes, E.
Joseph, U.
Fourment, M.
Su, Y.
Halpin, R.
Lee, R.
Deng, Y.
Gunalan, V.
Lin, X.
Stockwell, T.
Fedorova, N.
Zhou, B.
Spirason, N.
Küuhnert, D.
Bošková, V.
Stadler, T.
Costa, A.
Dwyer, D.
Huang, Q.
et al.
Citation: eLife, 2015; 4(1):e05055-1-e05055-23
Publisher: ELife Sciences
Issue Date: 2015
ISSN: 2050-084X
2050-084X
Statement of
Responsibility: 
Dhanasekaran Vijaykrishna, Edward C Holmes, Udayan Joseph, Mathieu Fourment, Yvonne CF Su, Rebecca Halpin, Raphael TC Lee, Yi-Mo Deng, Vithiagaran Gunalan, Xudong Lin, Timothy B Stockwell, Nadia B Fedorova, Bin Zhou, Natalie Spirason, Denise Kühnert, Veronika Bošková, Tanja Stadler, Anna-Maria Costa, Dominic E Dwyer, Q Sue Huang, Lance C Jennings, William Rawlinson, Sheena G Sullivan, Aeron C Hurt, Sebastian Maurer-Stroh, David E Wentworth, Gavin JD Smith, Ian G Barr
Abstract: A complex interplay of viral, host, and ecological factors shapes the spatio-temporal incidence and evolution of human influenza viruses. Although considerable attention has been paid to influenza A viruses, a lack of equivalent data means that an integrated evolutionary and epidemiological framework has until now not been available for influenza B viruses, despite their significant disease burden. Through the analysis of over 900 full genomes from an epidemiological collection of more than 26,000 strains from Australia and New Zealand, we reveal fundamental differences in the phylodynamics of the two co-circulating lineages of influenza B virus (Victoria and Yamagata), showing that their individual dynamics are determined by a complex relationship between virus transmission, age of infection, and receptor binding preference. In sum, this work identifies new factors that are important determinants of influenza B evolution and epidemiology.
Keywords: Influenza B viruses
Rights: Copyright Vijaykrishna et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
DOI: 10.7554/eLife.05055
Grant ID: NHMRC
Appears in Collections:Aurora harvest 4
Medicine publications

Files in This Item:
File Description SizeFormat 
hdl_121176.pdfPublished version2.22 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.