Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/121268
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Type: Journal article
Title: Challenges of international oncology trial collaboration-a call to action
Author: Tang, M.
Joensuu, H.
Simes, R.J.
Price, T.J.
Yip, S.
Hague, W.
Sjoquist, K.M.
Zalcberg, J.
Citation: British Journal of Cancer, 2019; 121(7):515-521
Publisher: Nature Publishing
Issue Date: 2019
ISSN: 0007-0920
1532-1827
Statement of
Responsibility: 
Monica Tang, Heikki Joensuu, Robert J. Simes, Timothy J. Price, Sonia Yip, Wendy Hague, Katrin M. Sjoquist and John Zalcberg
Abstract: International collaboration in oncology trials has the potential to enhance clinical trial activity by expediting the recruitment of large patient populations, testing treatments in diverse populations and facilitating the study of rare tumours or specific molecular subtypes. However, a number of challenges continue to hinder the efficient and productive conduct of both commercial and non-commercial international clinical trials. These challenges include complex and burdensome regulatory requirements, the high cost of conducting trials, and logistical challenges associated with ethics review, drug supply and biospecimen collection and management. We propose solutions to promote oncology trial collaboration, such as regulatory reform, harmonisation of trial initiation and management processes and greater recognition and funding of academic (non-commercial) clinical trials. It is only through coordinated effort and leadership from researchers, regulators and those responsible for health systems that the full potential of international trial collaboration can be realised.
Keywords: Cancer; drug development; research management
Rights: © The Author(s), under exclusive licence to Cancer Research UK 2019. This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International (CC BY 4.0).
RMID: 0030132469
DOI: 10.1038/s41416-019-0532-4
Grant ID: http://purl.org/au-research/grants/nhmrc/1037786
Appears in Collections:Medicine publications

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