Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/121276
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Type: Journal article
Title: Mass spectrometry analyses of multicellular tumor spheroids
Author: Acland, M.
Mittal, P.
Lokman, N.
Klingler-Hoffmann, M.
Oehler, M.
Hoffmann, P.
Citation: Proteomics: Clinical Applications, 2018; 12(3):1700124-1-1700124-13
Publisher: Wiley
Issue Date: 2018
ISSN: 1862-8346
1862-8354
Statement of
Responsibility: 
Mitchell Acland, Parul Mittal, Noor A. Lokman, Manuela Klingler-Hoffmann, Martin K. Oehler, and Peter Hoffmann
Abstract: Multicellular tumor spheroids (MCTS) are a powerful biological in vitro model, which closely mimics the 3D structure of primary avascularized tumors. Mass spectrometry (MS) has established itself as a powerful analytical tool, not only to better understand and describe the complex structure of MCTS, but also to monitor their response to cancer therapeutics. The first part of this review focuses on traditional mass spectrometry approaches with an emphasis on elucidating the molecular characteristics of these structures. Then the mass spectrometry imaging (MSI) approaches used to obtain spatially defined information from MCTS is described. Finally the analysis of primary spheroids, such as those present in ovarian cancer, and the great potential that mass spectrometry analysis of these structures has for improved understanding of cancer progression and for personalized in vitro therapeutic testing is discussed.
Keywords: Cancer; drug resistance; mass spectrometry-LC-MS/MS; mass spectrometry-MALDI-TOF; multicellular tumor spheroids; ovarian cancer
Rights: © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
DOI: 10.1002/prca.201700124
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