Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/121326
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Type: Journal article
Title: Dual-phase PET-CT to differentiate [¹⁸F]fluoromethylcholine uptake in reactive and malignant lymph nodes in patients with prostate cancer
Other Titles: Dual-phase PET-CT to differentiate [(18)F]fluoromethylcholine uptake in reactive and malignant lymph nodes in patients with prostate cancer
Author: Oprea-Lager, D.
Vincent, A.
van Moorselaar, R.
Gerritsen, W.
van den Eertwegh, A.
Eriksson, J.
Boellaard, R.
Hoekstra, O.
Citation: PLoS One, 2012; 7(10):e48430-e48430
Publisher: PLOS One
Issue Date: 2012
ISSN: 1932-6203
1932-6203
Editor: Rao, J.
Statement of
Responsibility: 
Daniela E. Oprea-Lager, Andrew D. Vincent, Reindert J. A. van Moorselaar, Winald R. Gerritsen, Alfons J. M. van den Eertwegh, Jonas Eriksson, Ronald Boellaard, Otto S. Hoekstra
Abstract: PURPOSE: To investigate whether time-trends of enhanced [(18)F]Fluoromethylcholine ([(18)F]FCH) in lymph nodes (LN) of prostate cancer (PCa) patients can help to discriminate reactive from malignant ones, and whether single time point standardized uptake value (SUV) measurements also suffice. PROCEDURES: 25 PCa patients with inguinal (presumed benign) and enlarged pelvic LN (presumed malignant) showing enhanced [(18)F]FCH uptake at dual-phase PET-CT were analyzed. Associations between LN status (benign versus malignant) and SUV(max) and SUV(meanA50), determined at 2 min (early) and 30 min (late) post injection, were assessed. We considered two time-trends of [(18)F]FCH uptake: type A (SUV early > SUV late) and type B (SUV late ≥ SUV early). Histopathology and/or follow-up were used to confirm the assumption that LN with type A pattern are benign, and LN with type B pattern malignant. RESULTS: Analysis of 54 nodes showed that LN status, time-trends, and 'late' (30 min p.i.) SUV(max) and SUV(meanA50) parameters were strongly associated (P<0.0001). SUV(max) relative difference was the best LN status predictor. All but one inguinal LN showed a decreasing [(18)F]FCH uptake over time (pattern A), while 95% of the pelvic nodes presented a stable or increasing uptake (pattern B) type. CONCLUSIONS: Time-trends of enhanced [(18)F]FCH uptake can help to characterize lymph nodes in prostate cancer patients. Single time-point SUV measurements, 30 min p.i., may be a reasonable alternative for predicting benign versus malignant status of lymph nodes, but this remains to be validated in non-enlarged pelvic lymph nodes.
Keywords: Choline
Rights: 2012 Oprea-Lager et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI: 10.1371/journal.pone.0048430
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