Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/121468
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorClayton, P.en
dc.contributor.authorMcdonald, S.en
dc.contributor.authorRuss, G.en
dc.contributor.authorChadban, S.en
dc.date.issued2013en
dc.identifier.citationAbstracts of the 49th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, as published in Nephrology, 2013 / vol.18, iss.Suppl. 1, pp.43en
dc.identifier.issn1320-5358en
dc.identifier.issn1440-1797en
dc.identifier.urihttp://hdl.handle.net/2440/121468-
dc.descriptionAbstract #111en
dc.description.abstractBackground: Declining rates of acute rejection (AR) and the high rate of 1-year graft survival among patients with AR have prompted re-examination of AR as an outcome in the clinic and in trials. Yet AR and its treatment may directly or indirectly affect longer-term outcomes for kidney transplant recipients. Methods: To understand the long-term effect of AR on outcomes, we analyzed data from the Australia and New Zealand Dialysis and Transplant Registry, including 13,614 recipients of a primary kidney-only transplant between 1997 and 2017 with at least 6 months of graft function. The associations between AR within 6 months post-transplant and subsequent cause-specific graft loss and death were determined using Cox models adjusted for baseline donor, recipient, and transplant characteristics. Results: AR occurred in 2906 recipients (21.4%) and was associated with graft loss attributed to chronic allograft nephropathy (hazard ratio [HR], 1.39; 95% confidence interval [95% CI], 1.23 to 1.56) and recurrent AR beyond month 6 (HR, 1.85; 95% CI, 1.39 to 2.46). Early AR was also associated with death with a functioning graft (HR, 1.22; 95% CI, 1.08 to 1.36), and with death due to cardiovascular disease (HR, 1.30; 95% CI, 1.11 to 1.53) and cancer (HR, 1.35; 95% CI, 1.12 to 1.64). Sensitivity analyses restricted to subgroups with either biopsy-proven, antibody-mediated, or vascular rejection, or stratified by treatment response produced similar results. Conclusions: AR is associated with increased risks of longer-term graft failure and death, particularly death from cardiovascular disease and cancer. The results suggest AR remains an important short-term outcome to monitor in kidney transplantation and clinical trials.en
dc.description.statementofresponsibilityP Clayton, S McDonald, G Russ and S Chadbanen
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.rights© 2013 The Authors Nephrology. © 2013 Asian Pacific Society of Nephrology,en
dc.subjectKidney transplantationen
dc.titleLong-term outcomes following acute rejection in kidney transplant recipients: an ANZDATA analysisen
dc.typeConference itemen
dc.identifier.rmid0030120735en
dc.contributor.conference49th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (09 Sep 2013 - 13 Sep 2013 : Brisbane, QLD)en
dc.identifier.doi10.1111/nep.12121en
dc.identifier.pubid480848-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidClayton, P. [0000-0001-9190-6753]en
dc.identifier.orcidMcdonald, S. [0000-0001-6103-1386]en
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.