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Type: Journal article
Title: Mitochondria and female germline stem cells−a mitochondrial DNA perspective
Author: St John, J.C.
Citation: Cells, 2019; 8(8):852-1-852-15
Publisher: MDPI
Issue Date: 2019
ISSN: 2073-4409
Statement of
Justin C. St. John
Abstract: Mitochondria and mitochondrial DNA have important roles to play in development. In primordial germ cells, they progress from small numbers to populate the maturing oocyte with high numbers to support post-fertilization events. These processes take place under the control of significant changes in DNA methylation and other epigenetic modifiers, as well as changes to the DNA methylation status of the nuclear-encoded mitochondrial DNA replication factors. Consequently, the differentiating germ cell requires significant synchrony between the two genomes in order to ensure that they are fit for purpose. In this review, I examine these processes in the context of female germline stem cells that are isolated from the ovary and those derived from embryonic stem cells and reprogrammed somatic cells. Although our knowledge is limited in this respect, I provide predictions based on other cellular systems of what is expected and provide insight into how these cells could be used in clinical medicine.
Keywords: Mitochondria; mitochondrial DNA; mitochondrial DNA copy number; female germ cells; egg precursor cells; embryonic stem cells; DNA methylation; mtDNA set point
Rights: © 2019 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
RMID: 0030133004
DOI: 10.3390/cells8080852
Grant ID:
Appears in Collections:Medicine publications

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