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Type: Journal article
Title: Any news from the prokinetic front?
Author: Deane, A.
Chapman, M.
Abdelhamid, Y.
Citation: Current Opinion in Critical Care, 2019; 25(4):349-355
Publisher: Lippincott Williams & Wilkins
Issue Date: 2019
ISSN: 1070-5295
Statement of
Adam M. Deane, Marianne J. Chapman and Yasmine Ali Abdelhamid
Abstract: PURPOSE OF REVIEW:This review provides an update of recently conducted studies and randomized controlled trials evaluating prokinetic drugs. RECENT FINDINGS:Prokinetic drugs accelerate gastric emptying and, particularly in patients with gastric dysmotility and enteral feed intolerance, their use increases the delivery of enteral nutrition. However, prokinetic drugs have not been shown to improve patient-centered outcomes in trials but benefit is assumed on the basis of observational studies, which report close associations between gastric dysmotility, enteral feed intolerance and poor outcomes, and improvement in surrogate physiological outcomes when prokinetic drugs are administered. SUMMARY:It may not be feasible to establish superiority of a prokinetic drug within a randomized controlled trial with a patient-centered event as the primary outcome. The use of metoclopramide and erythromycin as prokinetic drugs is based on observations from trials measuring surrogate physiological outcomes. Randomized controlled trials of alternative drug regimens and novel prokinetic drugs have recently been completed and results outlined.
Keywords: Humans
Gastrointestinal Agents
Treatment Outcome
Enteral Nutrition
Gastric Emptying
Randomized Controlled Trials as Topic
Observational Studies as Topic
Rights: © 2019 Wolters Kluwer Health, Inc. All rights reserved.
DOI: 10.1097/MCC.0000000000000634
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