Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/121520
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Type: Journal article
Title: Placental glucocorticoid receptor isoforms in a sheep model of maternal allergic asthma
Author: Clifton, V.
McDonald, M.
Morrison, J.
Holman, S.
Lock, M.
Saif, Z.
Meakin, A.
Wooldridge, A.
Gatford, K.
Wallace, M.
Muhlhausler, B.
Bischof, R.
Moss, T.
Citation: Placenta, 2019; 83:33-36
Publisher: Elsevier
Issue Date: 2019
ISSN: 0143-4004
1532-3102
Statement of
Responsibility: 
Vicki L. Clifton, Megan McDonald, Janna L. Morrison, Stacey L. Holman, Mitchell C. Lock, Zarqa Saif, Ashley Meakin, Amy L. Wooldridge, Kathryn L. Gatford, Megan J. Wallace, Beverly S. Muhlhausler, Robert J. Bischof, Timothy J.M. Moss
Abstract: Maternal asthma increases the risk of adverse pregnancy outcomes and may affect fetal growth and placental function by differential effects on the expression of glucocorticoid receptor (GR) isoforms, leading to altered glucocorticoid signalling. Our aim was to examine the effect of maternal asthma on placental GR profiles using a pregnant sheep model of asthma. Nine known GR isoforms were detected. There was a significant increase in the expression of placental GR isoforms that are known to have low trans-activational activity in other species including GR A, GR P and GRγ which may result in a pro-inflammatory environment in the presence of allergic asthma.
Keywords: Placenta; Animals; Animals, Newborn; Sheep, Domestic; Asthma; Pregnancy Complications; Disease Models, Animal; Protein Isoforms; Receptors, Glucocorticoid; Pregnancy; Female
Rights: Crown Copyright © 2019 Published by Elsevier Ltd. All rights reserved.
RMID: 0030120822
DOI: 10.1016/j.placenta.2019.06.380
Grant ID: http://purl.org/au-research/grants/nhmrc/1043294
http://purl.org/au-research/grants/nhmrc/1041918
http://purl.org/au-research/grants/nhmrc/1136100
http://purl.org/au-research/grants/nhmrc/1083009
http://purl.org/au-research/grants/nhmrc/1066916
http://purl.org/au-research/grants/arc/FT170100431
Appears in Collections:Medicine publications

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