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Type: Journal article
Title: Placental glucocorticoid receptor isoforms in a sheep model of maternal allergic asthma
Author: Clifton, V.L.
McDonald, M.
Morrison, J.L.
Holman, S.L.
Lock, M.C.
Saif, Z.
Meakin, A.
Wooldridge, A.L.
Gatford, K.L.
Wallace, M.J.
Muhlhausler, B.S.
Bischof, R.J.
Moss, T.J.M.
Citation: Placenta, 2019; 83:33-36
Publisher: Elsevier
Issue Date: 2019
ISSN: 0143-4004
Statement of
Vicki L. Clifton, Megan McDonald, Janna L. Morrison, Stacey L. Holman, Mitchell C. Lock, Zarqa Saif, Ashley Meakin, Amy L. Wooldridge, Kathryn L. Gatford, Megan J. Wallace, Beverly S. Muhlhausler, Robert J. Bischof, Timothy J.M. Moss
Abstract: Maternal asthma increases the risk of adverse pregnancy outcomes and may affect fetal growth and placental function by differential effects on the expression of glucocorticoid receptor (GR) isoforms, leading to altered glucocorticoid signalling. Our aim was to examine the effect of maternal asthma on placental GR profiles using a pregnant sheep model of asthma. Nine known GR isoforms were detected. There was a significant increase in the expression of placental GR isoforms that are known to have low trans-activational activity in other species including GR A, GR P and GRγ which may result in a pro-inflammatory environment in the presence of allergic asthma.
Keywords: Placenta
Animals, Newborn
Sheep, Domestic
Pregnancy Complications
Disease Models, Animal
Protein Isoforms
Receptors, Glucocorticoid
Rights: Crown Copyright © 2019 Published by Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.placenta.2019.06.380
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