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|Title:||Comparative sequence alignment reveals River Buffalo genomic structural differences compared with cattle|
|Citation:||Genomics, 2019; 111(3):418-425|
|Wenli Li, Derek M. Bickhart, Luigi Ramunno, Daniela Iamartino, John L. Williams, George E. Liu|
|Abstract:||This study sought to characterize differences in gene content, regulation and structure between taurine cattle and river buffalo (one subspecies of domestic water buffalo) using the extensively annotated UMD3.1 cattle reference genome as a basis for comparisons. We identified 127 deletion CNV regions in river buffalo representing 5 annotated cattle genes. We also characterized 583 merged mobile element insertion (MEI) events within the upstream regions of annotated cattle genes. Transcriptome analysis in various tissue types on river buffalo confirmed the absence of four cattle genes. Four genes which may be related to phenotypic differences in meat quality and color, had upstream MEI predictions and were found to have significantly elevated expression in river buffalo compared with cattle. Our comparative alignment approach and gene expression analyses suggested a functional role for many genomic structural variations, which may contribute to the unique phenotypes of river buffalo.|
|Keywords:||Comparative genomics; cattle; river buffalo|
|Rights:||Published by Elsevier Inc.|
|Appears in Collections:||Animal and Veterinary Sciences publications|
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