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|Title:||Colloidally stabilized magnetic carbon nanotubes providing MRI contrast in mouse liver tumors|
|Citation:||Biomacromolecules, 2015; 16(3):790-797|
|Publisher:||American Chemical Society|
|Yue Liu, Benjamin W. Muir, Lynne J. Waddington, Tracey M. Hinton, Bradford A. Moffat, Xiaojuan Hao, Jieshan Qiu and Timothy C. Hughes|
|Abstract:||The use of medical imaging contrast agents may lead to improved patient prognosis by potentially enabling an earlier detection of diseases and therefore an earlier initiation of treatments. In this study, we fabricated superparamagnetic iron oxide (SPIO) nanoparticles within the inner cavity of multiwalled carbon nanotubes (MWCNTs) for the first time; thereby ensuring high mechanical stability of the nanoparticles. A simple, but effective, self-assembled coating with RAFT diblock copolymers ensured the SPIO-MWCNTs have a high dispersion stability under physiological conditions. In vivo acute tolerance testing in mice showed a high tolerance dose up to 100 mg kg–1. Most importantly, after administration of the material a 55% increase in tumor to liver contrast ratio was observed with in vivo MRI measurements compared to the preinjection image enhancing the detection of the tumor.|
|Keywords:||Cell Line, Tumor; Animals; Mice, Inbred BALB C; Humans; Liver Neoplasms, Experimental; Nanotubes, Carbon; Colloids; Contrast Media; Magnetic Resonance Imaging; Female; Nanocomposites; Magnetite Nanoparticles|
|Rights:||© 2015 American Chemical Society|
|Appears in Collections:||Medicine publications|
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