Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/121778
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Type: Journal article
Title: Ibopamine challenge testing differentiates glaucoma suspect, stable glaucoma and progressive glaucoma cases
Author: Landers, J.
Ullrich, K.
Craig, J.
Citation: Clinical and Experimental Ophthalmology, 2015; 43(9):808-814
Publisher: Wiley-Blackwell
Issue Date: 2015
ISSN: 1442-6404
1442-9071
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Responsibility: 
John Landers, Katja Ullrich, Jamie E Craig
Abstract: An ibopamine challenge is a novel technique for assessing glaucoma using ibopamine, a topical drug which temporarily increases aqueous production. We aimed to determine whether change in intraocular pressure (IOP) and/or optic cup volume (OCV) during the test differentiated between glaucoma patients at different stages of disease; namely, glaucoma suspects (GS), glaucoma patients who are stable (SG) and glaucoma patients who have demonstrated rapid progression (PG).Non-randomized clinical trial evaluating a diagnostic test.Sixty-one patients were recruited through glaucoma clinics at the Flinders Medical Centre (24 GS, 24 SG and 13 PG).Patients underwent IOP measurement and OCV assessment using optical coherence tomography. Two drops of ibopamine 2% solution were instilled into the study eye of each patient. After 45 min, IOP and OCV were reassessed. Changes from baseline were compared between groups.Change in IOP and OCV after ibopamine challenge.Following the ibopamine challenge, IOP increased by 1.8 mmHg for GS patients, 4.5 mmHg for SG patients (P = 0.003) and 8.1 mmHg for PG patients (P < 0.0001). OCV increased by 0.2% for GS patients, 0.6% for SG patients and 5.5% for PG patients. This was not significantly different between GS patients and SG patients; however, it was significantly different between GS patients and PG patients (P < 0.0001), and between SG and PG patients (P = 0.001).GS patients may be differentiated from those with SG or PG by their IOP response, and SG may be differentiated from PG patients by their change in OCV following an ibopamine challenge.
Keywords: Challenge test; glaucoma; ibopamine; progression; suspect
Rights: © 2015 Royal Australian and New Zealand College of Ophthalmologists
DOI: 10.1111/ceo.12569
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