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Type: Journal article
Title: Neurochemical and thermal control of surfactant secretion by alveolar type II cells isolated from the marsupial, Sminthopsis crassicaudata
Author: Lang, C.
Daniels, C.
Orgeig, S.
Citation: Journal of Comparative Physiology B: biochemical, systemic, and environmental physiology, 2001; 171(3):223-230
Publisher: Springer-Verlag
Issue Date: 2001
ISSN: 0174-1578
Statement of
Ormond C.J, Daniels C.B and Orgeig S.
Abstract: Pulmonary surfactant is synthesised in alveolar type II cells and secreted into the lining of the lung in response to ventilation, temperature changes and autonomic neurotransmitters. Type II cells were isolated from the heterothermic marsupial, Sminthopsis crassicaudata. The neurotransmitters, isoproterenol and carbamylcholine chloride significantly increased phosphatidylcholine secretion at 37 degrees C (basal: 14.2%, isoproterenol: 20.1%, carbamylcholine: 17.0%). Temperature reduced the rate of secretion from dunnart type II cells (e.g. basal: 14.2% at 37 degrees C; 7.2% at 18 degrees C). However, the change in secretory rate between 37 degrees C and 18 degrees C was less than expected if due to temperature alone (Q10= 1.4). The surfactant secretory pathway is therefore modulated by factors other than and in addition to, temperature. The response of dunnart type II cells to the agonists remained the same at both temperatures. Basal secretion was higher in dunnart type II cells (14.2% in 4 h) than has been reported in rat type II cells (1.9% in 3 h) and consequently, the agonist-stimulated increases in secretion from dunnart type II cells (41% above basal in 4 h) were much lower than observed for rat type II cells (200% above basal in 1.5 h).
Keywords: Pulmonary Alveoli
Neurotransmitter Agents
Pulmonary Surfactants
Cell Survival
Hot Temperature
DOI: 10.1007/s003600000165
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Appears in Collections:Aurora harvest 2
Ecology, Evolution and Landscape Science publications

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