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Type: Journal article
Title: Selective biocatalytic hydroxylation of unactivated methylene C-H bonds in cyclic alkyl substrates
Author: Sarkar, M.R.
Dasgupta, S.
Pyke, S.M.
Bell, S.G.
Citation: Chemical Communications, 2019; 55(34):5029-5032
Publisher: Royal Society of Chemistry
Issue Date: 2019
ISSN: 1359-7345
Statement of
Md Raihan Sarkar, Samrat Dasgupta, Simon M. Pyke and Stephen G. Bell
Abstract: The cytochrome P450 monooxygenase CYP101B1 from Novosphingobium aromaticivorans selectively hydroxylated methylene C-H bonds in cycloalkyl rings. Cycloketones and cycloalkyl esters containing C6, C8, C10 and C12 rings were oxidised with high selectively on the opposite side of the ring to the carbonyl substituent. Cyclodecanone was oxidised to oxabicycloundecanol derivatives in equilibrium with the hydroxycyclodecanones.
Keywords: Biocatalytic hydroxylation
Rights: This journal is © The Royal Society of Chemistry 2019
DOI: 10.1039/c9cc02060h
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