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Type: Journal article
Title: A phantom for diffusion-weighted MRI (DW-MRI)
Author: Lavdas, I.
Behan, K.C.
Papadaki, A.
McRobbie, D.W.
Aboagye, E.O.
Citation: Journal of Magnetic Resonance Imaging, 2013; 38(1):173-179
Publisher: Wiley
Issue Date: 2013
ISSN: 1053-1807
Statement of
Ioannis Lavdas, Kevin C. Behan, Annie Papadaki, Donald W. McRobbie, Eric O. Aboagye
Abstract: To develop tissue-equivalent diffusivity materials and build a spherical diffusion phantom which mimics the conditions typically found in biological tissues. Also, to assess the reproducibility of ADC measurements from a whole-body diffusion protocol.Nickel-doped agarose/sucrose gels were manufactured and used to build a spherical diffusion phantom with tissue-equivalent relaxation and diffusion compartments. The temporal stability of the gels was monitored for a period of 8 weeks and, using the same measurements, the reproducibility of ADC was assessed in a 1.5 Tesla (T) clinical system.The temporal stability of the nickel-doped agarose/sucrose gels diffusion properties was excellent (average coefficient of variation [CV] for ADC in all phantom compartments = 1.27%). The average CV for ADC measurements, excluding the phantom compartments affected by artifacts, was 0.76% showing that the reproducibility of ADC measurements using an EPI DW-MRI protocol is very good.Nickel-doped agarose/sucrose gels can be used as reference materials for MRI diffusion measurements and show excellent short-term stability with respect to ADC. A phantom made of these materials can be invaluable in optimizing DW-MRI protocols, developing novel pulse sequences for DW-MRI, or comparing ADC values among field strengths, vendors, and imaging centers.
Keywords: Diffusion‐weighted MRI; tissue‐equivalent diffusivity materials; diffusion phantom; apparent diffusion coefficient; temporal stability; reproducibility
Rights: © 2013 Wiley Periodicals, Inc.
DOI: 10.1002/jmri.23950
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