Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/122002
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dc.contributor.author | O'Brien, C. | - |
dc.contributor.author | Louise, J. | - |
dc.contributor.author | Deussen, A. | - |
dc.contributor.author | Dodd, J.M. | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | BMC Endocrine Disorders, 2019; 19(1):97-97 | - |
dc.identifier.issn | 1472-6823 | - |
dc.identifier.issn | 1472-6823 | - |
dc.identifier.uri | http://hdl.handle.net/2440/122002 | - |
dc.description.abstract | BACKGROUND:To determine the association between maternal cardiometabolic and inflammatory markers with measures of fetal biometry and adiposity. METHODS:Women included in this exploratory analysis were randomised to the 'Standard Care' group (N = 911) from the LIMIT randomised trial involving a total of 2212 pregnant women who were overweight or obese (ACTRN12607000161426, Date of registration 9/03/2007, prospectively registered). Fetal biometry including abdominal circumference (AC), estimated fetal weight (EFW), and adiposity measurements (mid-thigh fat mass, subscapular fat mass, abdominal fat mass) were obtained from ultrasound assessments at 28 and 36 weeks' gestation. Maternal markers included C reactive protein (CRP), leptin and adiponectin concentrations, measured at 28 and 36 weeks' gestation and fasting triglycerides and glucose concentrations measured at 28 weeks' gestation. RESULTS:There were negative associations identified between maternal serum adiponectin and fetal ultrasound markers of biometry and adiposity. After adjusting for confounders, a 1-unit increase in log Adiponectin was associated with a reduction in the mean AC z score [- 0.21 (- 0.35, - 0.07), P = 0.004] and EFW [- 0.23 (- 0.37, - 0.10), P < 0.001] at 28 weeks gestation. Similarly, a 1-unit increase in log Adiponectin was association with a reduction in the mean AC z score [- 0.30 (- 0.46, - 0.13), P < 0.001] and EFW [- 0.24 (- 0.38, - 0.10), P < 0.001] at 36 weeks gestation. There were no consistent associations between maternal cardiometabolic and inflammatory markers with measurements of fetal adiposity. CONCLUSION:Adiponectin concentrations are associated with measures of fetal growth. Our findings contribute to further understanding of fetal growth in the setting of women who are overweight or obesity. | - |
dc.description.statementofresponsibility | Cecelia M. O’Brien, Jennie Louise, Andrea Deussen and Jodie M. Dodd | - |
dc.language.iso | en | - |
dc.publisher | Springer | - |
dc.rights | © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | - |
dc.source.uri | http://dx.doi.org/10.1186/s12902-019-0416-x | - |
dc.subject | Adiponectin | - |
dc.subject | Cardiometabolic markers | - |
dc.subject | Fetal body composition | - |
dc.subject | Obesity | - |
dc.subject | Pregnancy | - |
dc.title | Maternal cardiometabolic markers are associated with fetal growth: a secondary exploratory analysis of the LIMIT randomised trial | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1186/s12902-019-0416-x | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/627005 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/519240 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Louise, J. [0000-0001-5785-0290] | - |
dc.identifier.orcid | Deussen, A. [0000-0001-6210-1876] | - |
dc.identifier.orcid | Dodd, J.M. [0000-0002-6363-4874] | - |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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