Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/122041
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dc.contributor.authorMyles, H.en
dc.contributor.authorMyles, N.en
dc.contributor.authorCoetzer, C.en
dc.contributor.authorAdams, R.en
dc.contributor.authorChandratilleke, M.en
dc.contributor.authorLiu, D.en
dc.contributor.authorMercer, J.en
dc.contributor.authorVakulin, A.en
dc.contributor.authorVincent, A.en
dc.contributor.authorWittert, G.en
dc.contributor.authorGalletly, C.en
dc.date.issued2019en
dc.identifier.citationSchizophrenia Research: Cognition, 2019; 15:14-20en
dc.identifier.issn2215-0013en
dc.identifier.issn2215-0013en
dc.identifier.urihttp://hdl.handle.net/2440/122041-
dc.description.abstractPrevious studies have shown that people with schizophrenia have high rates of Obstructive Sleep Apnoea (OSA). Despite this, intervention studies to treat OSA in this population have not been undertaken. The ASSET (Assessing Sleep in Schizophrenia and Evaluating Treatment) pilot study investigated Continuous Positive Airway Pressure (CPAP) treatment of severe OSA in participants recruited from a clozapine clinic in Adelaide. Participants with severe untreated OSA (Apnoea-Hypopnoea Index (AHI) > 30), were provided with CPAP treatment, and assessed at baseline and six months across the following domains: physical health, quality of sleep, sleepiness, cognition, psychiatric symptoms and CPAP adherence. Six of the eight ASSET participants with severe OSA accepted CPAP. At baseline, half of the cohort had hypertension, all were obese with a mean BMI of 45, and they scored on average 1.47 standard deviations below the normal population in cognitive testing. The mean AHI was 76.8 and sleep architecture was markedly impaired with mean rapid eye movement (REM) sleep 4.1% and mean slow wave sleep (SWS) 4.8%. After six months of treatment there were improvements in cognition (BACS Z score improved by an average of 0.59) and weight loss (mean weight loss 7.3 ± 9 kg). Half of the participants no longer had hypertension and sleep architecture improved with mean REM sleep 31.4% of the night and mean SWS 24% of the night. Our data suggests CPAP may offer novel benefits to address cognitive impairment and sleep disturbance in people with schizophrenia.en
dc.description.statementofresponsibilityHannah Myles, Nicholas Myles, Ching Li Chai Coetzer, Robert Adams, Madhu Chandratilleke, Dennis Liu, Jeremy Mercer, Andrew Vakulin, Andrew Vincent, Gary Wittert, Cherrie Galletlyen
dc.language.isoenen
dc.publisherElsevieren
dc.rights© 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).en
dc.titleCognition in schizophrenia improves with treatment of severe obstructive sleep apnoea: a pilot studyen
dc.typeJournal articleen
dc.identifier.rmid0030102971en
dc.identifier.doi10.1016/j.scog.2018.09.001en
dc.identifier.pubid448575-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidLiu, D. [0000-0001-9180-2620]en
dc.identifier.orcidVincent, A. [0000-0002-6428-1070]en
dc.identifier.orcidWittert, G. [0000-0001-6818-6065]en
dc.identifier.orcidGalletly, C. [0000-0001-6185-9677]en
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