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Type: Journal article
Title: Associations of cord blood fatty acids with lymphocyte proliferation, IL-13, and IFN-γ
Other Titles: Associations of cord blood fatty acids with lymphocyte proliferation, IL-13, and IFN-gamma
Author: Gold, D.R.
Willwerth, B.M.
Tantisira, K.G.
Finn, P.W.
Schaub, B.
Perkins, D.L.
Tzianabos, A.
Ly, N.P.
Schroeter, C.
Gibbons, F.
Campos, H.
Oken, E.
Gillman, M.W.
Palmer, L.J.
Ryan, L.M.
Weiss, S.T.
Citation: Journal of Allergy and Clinical Immunology, 2006; 117(4):931-938
Publisher: Elsevier
Issue Date: 2006
ISSN: 0091-6749
Statement of
Diane R. Gold, Ben M. Willwerth, Kelan G. Tantisira, Patricia W. Finn, Bianca Schaub, David L. Perkins, Arthur Tzianabos, Ngoc P. Ly, Christian Schroeter, Fiona Gibbons, Hannia Campos, Emily Oken, Matthew W. Gillman, Lyle J. Palmer, Louise M. Ryan, and Scott T. Weiss
Abstract: BACKGROUND:N-3 and n-6 polyunsaturated fatty acids (PUFAs) have been hypothesized to have opposing influences on neonatal immune responses that might influence the risk of allergy or asthma. However, both n-3 eicosapentaenoic acid (EPA) and n-6 arachidonic acid (AA) are required for normal fetal development. OBJECTIVE:We evaluated whether cord blood fatty acid levels were related to neonatal immune responses and whether n-3 and n-6 PUFA responses differed. METHODS:We examined the relation of cord blood plasma n-3 and n-6 PUFAs (n = 192) to antigen- and mitogen-stimulated cord blood lymphocyte proliferation (n = 191) and cytokine (IL-13 and IFN-gamma; n = 167) secretion in a US birth cohort. RESULTS:Higher levels of n-6 linoleic acid were correlated with higher IL-13 levels in response to Bla g 2 (cockroach, P = .009) and Der f 1 (dust mite, P = .02). Higher n-3 EPA and n-6 AA levels were each correlated with reduced lymphocyte proliferation and IFN-gamma levels in response to Bla g 2 and Der f 1 stimulation. Controlling for potential confounders, EPA and AA had similar independent effects on reduced allergen-stimulated IFN-gamma levels. If neonates had either EPA or AA levels in the highest quartile, their Der f 1 IFN-gamma levels were 90% lower (P = .0001) than those with both EPA and AA levels in the lowest 3 quartiles. Reduced AA/EPA ratio was associated with reduced allergen-stimulated IFN-gamma level. CONCLUSION:Increased levels of fetal n-3 EPA and n-6 AA might have similar effects on attenuation of cord blood lymphocyte proliferation and IFN-gamma secretion. CLINICAL IMPLICATIONS:The implications of these findings for allergy or asthma development are not yet known.
Keywords: Asthma; child; cord blood; cytokine; fatty acids; lymphocyte proliferation
Rights: © 2006 American Academy of Allergy, Asthma and Immunology
DOI: 10.1016/j.jaci.2005.12.1322
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