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Type: Journal article
Title: A life course approach to cardiovascular aging
Author: Hardy, R.
Lawlor, D.A.
Kuh, D.
Citation: Future Cardiology, 2015; 11(1):101-113
Publisher: Future Science Group
Issue Date: 2015
ISSN: 1479-6678
Statement of
Rebecca Hardy, Debbie A Lawlor and Diana Kuh
Abstract: A life course approach in epidemiology investigates the biological, behavioral and social pathways that link physical and social exposures and experiences during gestation, childhood, adolescence and adult life, and across generations, to later-life health and disease risk. We illustrate how a life course approach has been applied to cardiovascular disease, highlighting the evidence in support of the early origins of disease risk. We summarize how trajectories of cardiometabolic risk factors change over the life course and suggest that understanding underlying 'normal' or 'healthy' trajectories and the characteristics that drive deviations from such trajectories offer the potential for early prevention and for identifying means of preventing future disease.
Keywords: Adiposity; birth weight; blood pressure; cardiovascular disease; cohort studies; glucose; life course; lipids; longitudinal modeling; social inequalities
Rights: © Rebecca Hardy, Diana Kuh, Debbie Lawler
DOI: 10.2217/fca.14.67
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