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Type: Journal article
Title: Photocontrol of peptide secondary structure through non-azobenzene photoswitches
Author: Peddie, V.
Abell, A.D.
Citation: Journal of Photochemistry and Photobiology C: Photochemical Reviews, 2019; 40:1-20
Publisher: Elsevier
Issue Date: 2019
ISSN: 1389-5567
Statement of
Victoria Peddie, Andrew D. Abell
Abstract: The rapidly expanding field of photoswitchable biomolecules is a major frontier in scientific research and provides unparalleled opportunities for studying biological pathways and disease progression. In particular, the development of photochromic peptides has delivered both scientific tools and candidates for photopharmaceuticals. The action and function of the peptide can be remotely altered using light, allowing detection of its biological role in complex biological settings, while also enabling folding studies that provide greater understanding of protein structure dynamics. In this review we provide a key, comprehensive overview of the different types of photoswitches that have been used to control peptide structure, excluding the already extensively reviewed azobenzene. This will help address the question as to which synthetic photoswitch to use in a given study.
Keywords: Isomerization; peptide; peptidomimetics; photoswitching; secondary structure
Rights: © 2019 Elsevier B.V. All rights reserved.
DOI: 10.1016/j.jphotochemrev.2019.05.001
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Appears in Collections:Aurora harvest 4
Chemical Engineering publications

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