Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/123087
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Type: Journal article
Title: Targeting malaria parasite invasion of red blood cells as an antimalarial strategy
Author: Burns, A.L.
Dans, M.G.
Balbin, J.M.
F de Koning-Ward, T.
Gilson, P.R.
Beeson, J.G.
Boyle, M.J.
Wilson, D.W.
Citation: FEMS Microbiology Reviews, 2019; 43(3):223-238
Publisher: Oxford University Press
Issue Date: 2019
ISSN: 0168-6445
1574-6976
Statement of
Responsibility: 
Amy L. Burns, Madeline G. Dans, Juan M. Balbin, Tania F. de Koning-Ward, Paul R. Gilson, James G. Beeson, Michelle J. Boyle, and Danny W. Wilson
Abstract: Plasmodium spp. parasites that cause malaria disease remain a significant global-health burden. With the spread of parasites resistant to artemisinin combination therapies in Southeast Asia, there is a growing need to develop new antimalarials with novel targets. Invasion of the red blood cell by Plasmodium merozoites is essential for parasite survival and proliferation, thus representing an attractive target for therapeutic development. Red blood cell invasion requires a co-ordinated series of protein/protein interactions, protease cleavage events, intracellular signals, organelle release and engagement of an actin-myosin motor, which provide many potential targets for drug development. As these steps occur in the bloodstream, they are directly susceptible and exposed to drugs. A number of invasion inhibitors against a diverse range of parasite proteins involved in these different processes of invasion have been identified, with several showing potential to be optimised for improved drug-like properties. In this review, we discuss red blood cell invasion as a drug target and highlight a number of approaches for developing antimalarials with invasion inhibitory activity to use in future combination therapies.
Keywords: Malaria; merozoites; invasion; antimalarial(s); P. falciparum; P. vivax
Rights: © FEMS 2019. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
DOI: 10.1093/femsre/fuz005
Grant ID: http://purl.org/au-research/grants/nhmrc/1035715
http://purl.org/au-research/grants/nhmrc/1143974
http://purl.org/au-research/grants/nhmrc/1141632
http://purl.org/au-research/grants/nhmrc/112656
http://purl.org/au-research/grants/nhmrc/1077636
http://purl.org/au-research/grants/nhmrc/1136300
ARC
Appears in Collections:Aurora harvest 8
Molecular and Biomedical Science publications

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