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|Title:||Apoptosis in megakaryocytes and platelets: the life and death of a lineage|
|Citation:||Blood, 2018; 131(6):605-610|
|Publisher:||American Society of Hematology|
|Kate McArthur, Stephane Chappaz, and Benjamin T. Kile|
|Abstract:||Despite their profoundly different cellular composition, size, and function, megakaryocytes and platelets both depend on restraint of the intrinsic (or "mitochondrial") apoptosis pathway by BCL-2 family prosurvival proteins for their development and viability. Activation of the pathway contributes to the clearance of megakaryocytes following platelet shedding and constrains platelet lifespan in the circulation. Important questions remain as to how apoptosis is initiated in these cells at steady state and in response to pathophysiological insults.|
|Rights:||© 2018 by The American Society of Hematology|
|Appears in Collections:||Aurora harvest 4|
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