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Type: Journal article
Title: Apoptosis in megakaryocytes and platelets: the life and death of a lineage
Author: McArthur, K.
Chappaz, S.
Kile, B.
Citation: Blood, 2018; 131(6):605-610
Publisher: American Society of Hematology
Issue Date: 2018
ISSN: 0006-4971
Statement of
Kate McArthur, Stephane Chappaz, and Benjamin T. Kile
Abstract: Despite their profoundly different cellular composition, size, and function, megakaryocytes and platelets both depend on restraint of the intrinsic (or "mitochondrial") apoptosis pathway by BCL-2 family prosurvival proteins for their development and viability. Activation of the pathway contributes to the clearance of megakaryocytes following platelet shedding and constrains platelet lifespan in the circulation. Important questions remain as to how apoptosis is initiated in these cells at steady state and in response to pathophysiological insults.
Keywords: Blood Platelets
Rights: © 2018 by The American Society of Hematology
DOI: 10.1182/blood-2017-11-742684
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