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|dc.identifier.citation||Infection, Genetics and Evolution, 2019; 70:107-113||en|
|dc.description.abstract||Increasing reports of antimicrobial resistance in wildlife highlight the significance of a One Health approach to managing resistance. We investigated the prevalence and diversity of class 1 integrons, a genetic determinant of resistance, in grey-headed flying foxes, a large fruit bat species belonging to the order Chiroptera. Class 1 integrons were detected in both wild flying foxes (5.3%) and captive flying foxes (41.2%) housed in wildlife rehabilitation facilities. Genes encoding resistance to aminoglycosides, trimethoprim and beta-lactams, and Qac efflux pumps were detected. Analysis of conserved integron elements and gene cassette arrays indicate the direction of integron transfer is from humans to flying foxes. The detection of two novel gene cassette arrays (5'CS-qacH-aacA34-blaOXA-21-3'CS and 5'CS-qacF-3'CS strongly suggests acquisition of genes from the environmental resistome into class 1 integrons within the flying fox microbiota. The dynamics of class 1 integrons in flying foxes indicates bats have a role in the emergence of novel antibiotic resistance determinants.||en|
|dc.description.statementofresponsibility||Fiona McDougall, Wayne Boardman, Michael Gillings, Michelle Power||en|
|dc.rights||© 2019 Elsevier B.V. All rights reserved.||en|
|dc.subject||Antimicrobial resistance; bats; integron; One Health; resistome; reverse zoonosis||en|
|dc.title||Bats as reservoirs of antibiotic resistance determinants: a survey of class 1 integrons in grey-headed flying foxes (Pteropus poliocephalus)||en|
|dc.identifier.orcid||Boardman, W. [0000-0002-1746-0682]||en|
|Appears in Collections:||Animal and Veterinary Sciences publications|
Aurora harvest 4
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