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Type: Journal article
Title: Short-term (48 hours) intravenous serelaxin infusion has no effect on myogenic tone or vascular remodeling in rat mesenteric arteries
Author: Jelinic, M.
Leo, C.
Marshall, S.
Senadheera, S.
Parry, L.
Tare, M.
Citation: Microcirculation, 2017; 24(6):e12371-1-e12371-12
Publisher: Wiley
Issue Date: 2017
ISSN: 1073-9688
Statement of
Maria Jelinic, Chen Huei Leo, Sarah A. Marshall, Sevvandi N. Senadheera, Laura J. Parry, Marianne Tare
Abstract: Background: Short-term IV sRLX (recombinant human relaxin-2) infusion enhances endothelium-dependent relaxation in mesenteric arteries. This is initially underpinned by increased NO followed by a transition to prostacyclin. The effects of short-term IV sRLX treatment on pressure-induced myogenic tone and vascular remodeling in these arteries are unknown. Therefore, we investigated the effects of sRLX infusion on pressure-induced myogenic tone and passive mechanical wall properties in mesenteric arteries. Methods: Mesenteric artery myogenic tone and passive mechanics were examined after 48-hours and 10-days infusion of sRLX. Potential mechanisms of action were assessed by pressure myography, qPCR, and Western blot analysis. Results: Neither 48-hours nor 10-days sRLX treatment had significant effects on myogenic tone, passive arterial wall stiffness, volume compliance, or axial lengthening. However, in 48-hours sRLX -treated rats, incubation with the NO synthase blocker L-NAME significantly increased myogenic tone (P<.05 vs placebo), demonstrating an increased contribution of NO to the regulation of myogenic tone. eNOS dimerization, but not phosphorylation, was significantly upregulated in the arteries of sRLX -treated rats. Conclusion: In mesenteric arteries, 48-hours sRLX treatment upregulates the role of NO in the regulation of myogenic tone by enhancing eNOS dimerization, without altering overall myogenic tone or vascular remodeling.
Keywords: Myogenic tone; nitric oxide; relaxin; vascular stiffness
Rights: © 2017 John Wiley & Sons Ltd
RMID: 1000004950
DOI: 10.1111/micc.12371
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Appears in Collections:Pharmacology publications

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