Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/123456
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Type: Journal article
Title: Inguinal and ilio-inguinal lymphadenectomy in management of palpable melanoma lymph node metastasis: a long-term prospective evaluation of morbidity and quality of life
Author: Henderson, M.A.
Gyorki, D.
Burmeister, B.H.
Ainslie, J.
Fisher, R.
Di Iulio, J.
Smithers, B.M.
Hong, A.
Shannon, K.
Scolyer, R.A.
Carruthers, S.
Coventry, B.J.
Babington, S.
Duprat, J.
Hoekstra, H.J.
Thompson, J.F.
Citation: Annals of Surgical Oncology, 2019; 26(13):4663-4672
Publisher: Springer Nature
Issue Date: 2019
ISSN: 1068-9265
1534-4681
Statement of
Responsibility: 
Michael A. Henderson, D. Gyorki, B.H. Burmeister, J. Ainslie, R. Fisher, J. Di Iulio, B.M. Smithers, A. Hong, K. Shannon, R.A. Scolyer, S. Carruthers, B.J. Coventry, S. Babington, J. Duprat, H.J. Hoekstra, and J.F. Thompson
Abstract: Purpose: Prospective data are lacking on long-term morbidity of inguinal lymphadenectomy including the influence of extent of surgery, use of radiotherapy, and patient factors. The aim of this study is to evaluate the effects of these factors on patient outcome, quality of life (QOL), regional symptoms, and limb volumes after inguinal or ilio-inguinal lymphadenectomy for melanoma. Methods: Analysis of the subgroup of patients with inguinal lymph node field relapse of melanoma, treated by inguinal or ilio-inguinal lymphadenectomy in the ANZMTG/TROG randomized trial of adjuvant radiotherapy versus observation. Results: Sixty-nine patients, 46 having undergone inguinal and 23 ilio-inguinal lymphadenectomy, with median follow-up of 73 months were analyzed. Mean limb volume increased rapidly after surgery (7% by 3 months) and continued to increase for at least another 18 months. Patients with body mass index (BMI) ≥ 25 kg/m2 had greater limb volume increase than normal-weight patients (13.3% versus 6.9%, P = 0.030). QOL improved over the first 18 months, but despite initial improvement, regional symptoms persisted long term. Type of surgery (inguinal or ilio-inguinal lymphadenectomy) had no demonstrably significant effect on limb volume (9.9% versus 13.4%, P = 0.35), QOL (P = 0.68), or regional symptoms (P = 0.65). There was no difference in overall survival between inguinal and ilio-inguinal lymphadenectomy [hazard ratio (HR) 0.75, 95% confidence interval (CI) 0.40-1.40, P = 0.43]. Conclusions: Inguinal lymphadenectomy for melanoma is a potentially morbid procedure with significant increases in limb volume. Patients report reasonable QOL but may have ongoing regional symptoms. Overweight/obesity is associated with poorer QOL, increased limb volume, and regional symptoms.
Keywords: Inguinal Canal
Ilium
Lymph Nodes
Humans
Melanoma
Lymphatic Metastasis
Prognosis
Lymph Node Excision
Morbidity
Survival Rate
Follow-Up Studies
Prospective Studies
Quality of Life
Adult
Aged
Middle Aged
Disease Management
Female
Male
Rights: © Society of Surgical Oncology 2019
DOI: 10.1245/s10434-019-07810-0
Grant ID: NHMRC
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