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https://hdl.handle.net/2440/123545
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DC Field | Value | Language |
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dc.contributor.author | Leo, C.H. | - |
dc.contributor.author | Jelinic, M. | - |
dc.contributor.author | Ng, H.H. | - |
dc.contributor.author | Tare, M. | - |
dc.contributor.author | Parry, L.J. | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Trends in Pharmacological Sciences, 2016; 37(6):498-507 | - |
dc.identifier.issn | 0165-6147 | - |
dc.identifier.issn | 1873-3735 | - |
dc.identifier.uri | http://hdl.handle.net/2440/123545 | - |
dc.description.abstract | Vascular dysfunction is an important hallmark of cardiovascular disease. It is characterized by increased sensitivity to vasoconstrictors, decreases in the endothelium-derived vasodilators nitric oxide (NO) and prostacyclin (PGI2), and endothelium-derived hyperpolarization (EDH). Serelaxin (recombinant human relaxin) has gained considerable attention as a new vasoactive drug, largely through its beneficial therapeutic effects in acute heart failure. In this review we first describe the contribution of endogenous relaxin to vascular homeostasis. We then provide a comprehensive overview of the novel mechanisms of serelaxin action in blood vessels that differentiate it from other vasodilator drugs and explain how this peptide could be used more widely as a therapeutic to alleviate vascular dysfunction in several cardiovascular diseases. | - |
dc.description.statementofresponsibility | Chen Huei Leo, Maria Jelinic, Hooi Hooi Ng, MarianneTare, Laura J.Parry | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | © 2016 Published by Elsevier Ltd. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.tips.2016.04.001 | - |
dc.subject | Serelaxin; vascular dysfunction; endothelium; prostanoids; nitric oxide | - |
dc.title | Serelaxin: a novel therapeutic for vascular diseases | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.tips.2016.04.001 | - |
dc.relation.grant | NHMRC | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Parry, L.J. [0000-0002-6883-3418] | - |
Appears in Collections: | Aurora harvest 4 Pharmacology publications |
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