Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/123604
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKim, M.L.-
dc.contributor.authorChae, J.J.-
dc.contributor.authorPark, Y.H.-
dc.contributor.authorDe Nardo, D.-
dc.contributor.authorStirzaker, R.A.-
dc.contributor.authorKo, H.J.-
dc.contributor.authorTye, H.-
dc.contributor.authorCengia, L.-
dc.contributor.authorDiRago, L.-
dc.contributor.authorMetcalf, D.-
dc.contributor.authorRoberts, A.W.-
dc.contributor.authorKastner, D.L.-
dc.contributor.authorLew, A.M.-
dc.contributor.authorLyras, D.-
dc.contributor.authorKile, B.T.-
dc.contributor.authorCroker, B.A.-
dc.contributor.authorMasters, S.L.-
dc.date.issued2015-
dc.identifier.citationJournal of Experimental Medicine, 2015; 212(6):927-938-
dc.identifier.issn0022-1007-
dc.identifier.issn1540-9538-
dc.identifier.urihttp://hdl.handle.net/2440/123604-
dc.description.abstractGain-of-function mutations that activate the innate immune system can cause systemic autoinflammatory diseases associated with increased IL-1β production. This cytokine is activated identically to IL-18 by an intracellular protein complex known as the inflammasome; however, IL-18 has not yet been specifically implicated in the pathogenesis of hereditary autoinflammatory disorders. We have now identified an autoinflammatory disease in mice driven by IL-18, but not IL-1β, resulting from an inactivating mutation of the actin-depolymerizing cofactor Wdr1. This perturbation of actin polymerization leads to systemic autoinflammation that is reduced when IL-18 is deleted but not when IL-1 signaling is removed. Remarkably, inflammasome activation in mature macrophages is unaltered, but IL-18 production from monocytes is greatly exaggerated, and depletion of monocytes in vivo prevents the disease. Small-molecule inhibition of actin polymerization can remove potential danger signals from the system and prevents monocyte IL-18 production. Finally, we show that the inflammasome sensor of actin dynamics in this system requires caspase-1, apoptosis-associated speck-like protein containing a caspase recruitment domain, and the innate immune receptor pyrin. Previously, perturbation of actin polymerization by pathogens was shown to activate the pyrin inflammasome, so our data now extend this guard hypothesis to host-regulated actin-dependent processes and autoinflammatory disease.-
dc.description.statementofresponsibilityMan Lyang Kim, Jae Jin Chae, Yong Hwan Park, Dominic De Nardo, Roslynn A. Stirzaker ... Benjamin T Kile ... et al.-
dc.language.isoen-
dc.publisherRockefeller University Press-
dc.rights© 2015 Kim et al. This article is distributed under the terms of an Attribution– Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial– Share Alike 3.0 Unported license, as described at http://creativecommons.org/ licenses/by-nc-sa/3.0/).-
dc.source.urihttp://dx.doi.org/10.1084/jem.20142384-
dc.subjectMonocytes-
dc.titleAberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β-
dc.title.alternativeAberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1beta-
dc.typeJournal article-
dc.identifier.doi10.1084/jem.20142384-
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/361646-
dc.relation.grantARC-
pubs.publication-statusPublished-
dc.identifier.orcidKile, B.T. [0000-0002-8836-8947]-
Appears in Collections:Aurora harvest 4
Medical Sciences publications

Files in This Item:
File Description SizeFormat 
hdl_123604.pdfPublished version2.65 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.