Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/123605
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Type: Journal article
Title: Regulation of platelet lifespan in the presence and absence of thrombopoietin signaling
Author: Lebois, M.
Dowling, M.
Gangatirkar, P.
Hodgkin, P.
Kile, B.
Alexander, W.
Josefsson, E.
Citation: Journal of Thrombosis and Haemostasis, 2016; 14(9):1882-1887
Publisher: Wiley-Blackwell
Issue Date: 2016
ISSN: 1538-7933
1538-7836
Statement of
Responsibility: 
M. Lebois, M. R. Dowling, P. Gangatirkar, P. D. Hodgkin, B. T. Kile, W. S. Alexander and E. C. Josefsson
Abstract: Essentials We examined platelet survival in models of absent or enhanced thrombopoietin (TPO) signaling. Platelet lifespan is normal in transgenic mice with chronically enhanced TPO signaling. Mpl deficiency does not negatively affect platelet lifespan in the absence of thrombocytopenia. We conclude that TPO and its receptor Mpl are dispensable for platelet survival in adult mice.Background It is well established that thrombopoietin (TPO), acting via its receptor Mpl, is the major cytokine regulator of platelet biogenesis. The primary mechanism by which TPO signaling stimulates thrombopoiesis is via stimulation of Mpl-expressing hematopoietic progenitors; Mpl on megakaryocytes and platelets acts to control the amount of TPO available. TPO could potentially reduce platelet and/or megakaryocyte apoptosis, and therefore increase the platelet count. However, the effect of TPO receptor signaling on platelet survival is unresolved. Methods and results Here, we investigated platelet survival in mouse models of absent or enhanced TPO signaling. In the absence of thrombocytopenia, Mpl deficiency did not negatively influence platelet lifespan, and nor was platelet survival affected in transgenic mice with chronically increased TPO signaling. Conclusions We conclude that TPO and its receptor Mpl are dispensable for platelet survival in adult mice.
Keywords: Animal models; apoptosis; Mpl protein, mouse; platelets; thrombopoietin
Rights: © 2016 International Society on Thrombosis and Haemostasis.
RMID: 1000001811
DOI: 10.1111/jth.13397
Grant ID: http://purl.org/au-research/grants/nhmrc/1079250
http://purl.org/au-research/grants/nhmrc/1016647
http://purl.org/au-research/grants/nhmrc/1016701
http://purl.org/au-research/grants/nhmrc/1054925
http://purl.org/au-research/grants/nhmrc/1063008
http://purl.org/au-research/grants/nhmrc/1058344
http://purl.org/au-research/grants/nhmrc/0516788
http://purl.org/au-research/grants/nhmrc/1079136
http://purl.org/au-research/grants/nhmrc/9000220
Appears in Collections:Medical Sciences publications

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