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Type: Journal article
Title: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank
Author: Coleman, J.R.I.
Peyrot, W.J.
Purves, K.L.
Davis, K.A.S.
Rayner, C.
Choi, S.W.
Hübel, C.
Gaspar, H.A.
Kan, C.
Van der Auwera, S.
Adams, M.J.
Lyall, D.M.
Choi, K.W.
Wray, N.R.
Ripke, S.
Mattheisen, M.
Trzaskowski, M.
Byrne, E.M.
Abdellaoui, A.
Adams, M.J.
et al.
Citation: Molecular Psychiatry, 2020; Onlinepubl(7):1-17
Publisher: Springer Nature
Issue Date: 2020
ISSN: 1359-4184
Statement of
Jonathan R. I. Coleman, Wouter J. Peyrot, Kirstin L. Purves, Katrina A. S. Davis ... Tracy M. Air ... Bernhard T. Baune ... et al.
Abstract: Depression is more frequent among individuals exposed to traumatic events. Both trauma exposure and depression are heritable. However, the relationship between these traits, including the role of genetic risk factors, is complex and poorly understood. When modelling trauma exposure as an environmental influence on depression, both gene-environment correlations and gene-environment interactions have been observed. The UK Biobank concurrently assessed Major Depressive Disorder (MDD) and self-reported lifetime exposure to traumatic events in 126,522 genotyped individuals of European ancestry. We contrasted genetic influences on MDD stratified by reported trauma exposure (final sample size range: 24,094-92,957). The SNP-based heritability of MDD with reported trauma exposure (24%) was greater than MDD without reported trauma exposure (12%). Simulations showed that this is not confounded by the strong, positive genetic correlation observed between MDD and reported trauma exposure. We also observed that the genetic correlation between MDD and waist circumference was only significant in individuals reporting trauma exposure (rg = 0.24, p = 1.8 × 10-7 versus rg = -0.05, p = 0.39 in individuals not reporting trauma exposure, difference p = 2.3 × 10-4). Our results suggest that the genetic contribution to MDD is greater when reported trauma is present, and that a complex relationship exists between reported trauma exposure, body composition, and MDD.
Keywords: on the behalf of Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Genetic Predisposition to Disease
Depressive Disorder, Major
Databases, Factual
Middle Aged
Waist Circumference
Genome-Wide Association Study
Self Report
Gene-Environment Interaction
Psychological Trauma
United Kingdom
Description: Published: 23 January 2020
Rights: © The Author(s), under exclusive licence to Springer Nature Limited 2020.
DOI: 10.1038/s41380-019-0546-6
Appears in Collections:Aurora harvest 8
Psychiatry publications

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