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https://hdl.handle.net/2440/123704
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dc.contributor.author | Chen, A.X. | - |
dc.contributor.author | Moran, J.L. | - |
dc.contributor.author | Libianto, R. | - |
dc.contributor.author | Baqar, S. | - |
dc.contributor.author | O Callaghan, C. | - |
dc.contributor.author | MacIsaac, R.J. | - |
dc.contributor.author | Jerums, G. | - |
dc.contributor.author | Ekinci, E.I. | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Journal of Human Hypertension, 2019; 34(2):143-150 | - |
dc.identifier.issn | 0950-9240 | - |
dc.identifier.issn | 1476-5527 | - |
dc.identifier.uri | http://hdl.handle.net/2440/123704 | - |
dc.description.abstract | High blood pressure variability (BPV) has been associated with increased cardiovascular (CV) risk. The effect of dietary salt and renin-angiotensin-aldosterone system (RAAS) activity on short-term BPV in type 2 diabetes mellitus (T2DM) is not well characterised. We aimed to determine the effect of dietary salt (sodium chloride, NaCl) supplementation on 24-h mean arterial BPV (24hBPV) during angiotensin II receptor blocker (telmisartan) use and to evaluate the effects of age, sex, plasma renin activity (PRA) and serum aldosterone on 24hBPV. In a randomised, double-blind, crossover study, patients with T2DM (n = 28), treated with telmisartan received NaCl (100 mmol/24 h) or placebo capsules during 2 weeks of telmisartan. Following a 6-week washout, the protocol was repeated in reverse. 24hBPV was evaluated as a co-efficient of variation [CV (%) = mean/standard deviation] × 100). Twenty-four hour urinary sodium excretion, ambulatory BP and biochemical tests were performed at each phase. Results were analysed using a linear mixed model to generate predicted values for 24hBPV. Predicted 24hBPV was higher with telmisartan vs baseline (p = 0.01), with a trend towards reduced 24hBPV with salt (p = 0.052). Predicted 24hBPV was lower in females (p = 0.017), increasing age (p = 0.001) and increasing PRA (p = 0.011). In patients with T2DM, predicted 24hBPV increased from baseline with telmisartan, but there was no additional increase in predicted 24hBPV with salt supplementation. This suggests that in the short-term, salt supplementation has no apparent deleterious effects on 24hBPV. Long-term studies are required to evaluate the effect of 24hBPV on CV outcomes in patients with T2DM. | - |
dc.description.statementofresponsibility | Angela X. Chen, John L. Moran, Renata Libianto, Sara Baqar, Christopher O'Callaghan, Richard J. MacIsaac, George Jerums, Elif I. Ekinci | - |
dc.language.iso | en | - |
dc.publisher | Springer Nature | - |
dc.rights | © The Author(s), under exclusive licence to Springer Nature Limited 2019. | - |
dc.source.uri | http://dx.doi.org/10.1038/s41371-019-0238-3 | - |
dc.subject | Humans | - |
dc.subject | Hypertension | - |
dc.subject | Diabetes Mellitus, Type 2 | - |
dc.subject | Sodium Chloride | - |
dc.subject | Sodium Chloride, Dietary | - |
dc.subject | Aldosterone | - |
dc.subject | Renin | - |
dc.subject | Angiotensin II | - |
dc.subject | Cross-Over Studies | - |
dc.subject | Renin-Angiotensin System | - |
dc.subject | Blood Pressure | - |
dc.subject | Dietary Supplements | - |
dc.subject | Female | - |
dc.subject | Angiotensin Receptor Antagonists | - |
dc.title | Effect of angiotensin II receptor blocker and salt supplementation on short-term blood pressure variability in type 2 diabetes | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1038/s41371-019-0238-3 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/466611 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1054312 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Moran, J.L. [0000-0003-2311-0440] | - |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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