Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Full metadata record
DC FieldValueLanguage
dc.contributor.authorGriesser, S.-
dc.contributor.authorJasieniak, M.-
dc.contributor.authorCoad, B.-
dc.contributor.authorGriesser, H.-
dc.identifier.citationBiointerphases: an open access journal for the biomaterials interface community, 2015; 10(4):04A307-1-04A307-9-
dc.descriptionPublished Online: 14 October 2015-
dc.description.abstractNot only bacteria but also fungal pathogens, particularly Candida species, can lead to biofilm infections on biomedical devices. By covalent grafting of the antifungal drug caspofungin, which targets the fungal cell wall, onto solid biomaterials, a surface layer can be created that might be able to provide long-term protection against fungal biofilm formation. Plasma polymerization of propionaldehyde (propanal) was used to deposit a thin (∼20 nm) interfacial bonding layer bearing aldehyde surface groups that can react with amine groups of caspofungin to form covalent interfacial bonds for immobilization. Surface analyses by x-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry confirmed the intended grafting and uniformity of the coatings, and durability upon extended washing. Testing for fungal cell attachment and ensuing biofilm formation showed that caspofungin retained activity when covalently bound onto surfaces, disrupting colonizing Candida cells. Mammalian cytotoxicity studies using human primary fibroblasts indicated that the caspofungin-grafted surfaces were selective in eliminating fungal cells while allowing attachment and spreading of mammalian cells. These in vitro data suggest promise for use as antifungal coatings, for example, on catheters, and the use of a plasma polymer interlayer enables facile transfer of the coating method onto a wide variety of biomaterials and biomedical devices.-
dc.description.statementofresponsibilityStefani S. Griesser, Marek Jasieniak, Bryan R. Coad, and Hans J. Griesser-
dc.publisherAVS: Science and Technology of Materials, Interfaces and Processing-
dc.rights© 2015 American Vacuum Society-
dc.titleAntifungal coatings by caspofungin immobilization onto biomaterials surfaces via a plasma polymer interlayer-
dc.typeJournal article-
dc.identifier.orcidCoad, B. [0000-0003-3297-3977]-
Appears in Collections:Agriculture, Food and Wine publications
Aurora harvest 8

Files in This Item:
File Description SizeFormat 
hdl_123749.pdfPublished version4.11 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.