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Type: Journal article
Title: The diagnostic test accuracy of serum measurement of procalcitonin and C-reactive protein for bone and joint infection in children and adolescents: a systematic review protocol.
Author: Ritchie, B.
Porritt, K.
Marin, T.
Williams, N.
Citation: The JBI Database of Systematic Reviews and Implementation Reports, 2019
Publisher: Wolters Kluwer
Issue Date: 2019
ISSN: 2202-4433
Statement of
Brett Ritchie, Kylie Porritt, Tania Marin, Nicole Williams
Abstract: OBJECTIVE:To synthesize the best available evidence for the diagnostic test accuracy of procalcitonin (PCT) compared to C-reactive protein (CRP) in diagnosing osteomyelitis (OM) and septic arthritis, in hospitalized children and adolescents. INTRODUCTION:Serum measurement of PCT has been shown to outperform CRP in diagnosing adult osteoarticular infections. Before PCT can be considered as a potential diagnostic test in children and adolescents, a systematic review is required. INCLUSION CRITERIA:Children and adolescents aged one month to 18 years, admitted to hospital with suspected acute osteoarticular infection. Original studies measuring the diagnostic accuracy of PCT and/or CRP in the diagnosis of acute OM or septic arthritis, defined as: positive culture or polymerase chain reaction (PCR) confirmation of an accepted pathogen from blood, bone biopsy or joint fluid aspirate and/or at least two of the following: 1) purulent material from biopsy or aspirate specimen; 2) positive radiological findings of osteoarticular infection; 3) symptoms and signs consistent with OM/septic arthritis. METHODS:JBI methodology for systematic reviews of diagnostic test accuracy will be utilized. A three-step strategy will be undertaken to find relevant studies that will be assessed and reviewed using JBI SUMARI. A standardized critical appraisal tool will assess methodological quality of studies. The main outcome will be pooled sensitivity and specificity measures with 95% confidence intervals for PCT and CRP in OM or septic arthritis. Results will be presented using either paired forest plots, receiver operator characteristic curves and narrative synthesis, and will include a summary of findings table. SYSTEMATIC REVIEW REGISTRATION NUMBER:CRD42019140276.
Keywords: C-reactive protein (CRP); osteoarticular; osteomyelitis (OM); procalcitonin (PCT); septic arthritis
Rights: © 2020 Joanna Briggs Institute
DOI: 10.11124/jbisrir-d-19-00139
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