Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/123948
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Type: Journal article
Title: Antifungal activity in compounds from the Australian desert plant Eremophila alternifolia with potency against Cryptococcus spp
Author: Hossain, M.
Biva, I.
Kidd, S.
Whittle, J.
Griesser, H.
Coad, B.
Citation: Antibiotics, 2019; 8(2):34-1-34-12
Publisher: MDPI
Issue Date: 2019
ISSN: 2079-6382
2079-6382
Statement of
Responsibility: 
Diterpenoids; antifungal; wound healing; serrulatane; fungi; Eremophila; Cryptococcus; disk diffusion; broth microdilution
Abstract: Plant metabolites that have shown activity against bacteria and/or environmental fungi represent valuable leads for the identification and development of novel drugs against clinically important human pathogenic fungi. Plants from the genus Eremophila were highly valued in traditional Australian Aboriginal medicinal practices, and E. alternifolia was the most prized among them. As antibacterial activity of extracts from E. alternifolia has been documented, this study addresses the question whether there is also activity against infectious fungal human pathogens. Compounds from leaf-extracts were purified and identified by 1- and 2-D NMR. These were then tested by disk diffusion and broth microdilution assays against ten clinically and environmentally relevant yeast and mould species. The most potent activity was observed with the diterpene compound, 8,19-dihydroxyserrulat-14-ene against Cryptococcus gattii and Cryptococcus neoformans, with minimum inhibition concentrations (MIC) comparable to those of Amphotericin B. This compound also exhibited activity against six Candida species. Combined with previous studies showing an antibacterial effect, this finding could explain a broad antimicrobial effect from Eremophila extracts in their traditional medicinal usage. The discovery of potent antifungal compounds from Eremophila extracts is a promising development in the search for desperately needed antifungal compounds particularly for Cryptococcus infections.
Keywords: Diterpenoids; antifungal; wound healing; serrulatane; fungi; Eremophila; Cryptococcus; disk diffusion; broth microdilution
Rights: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
RMID: 0030118217
DOI: 10.3390/antibiotics8020034
Grant ID: http://purl.org/au-research/grants/nhmrc/1066647
Appears in Collections:Agriculture, Food and Wine publications

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