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Type: Journal article
Title: Annexin-A1 deficiency exacerbates pathological remodelling of the mesenteric vasculature in insulin-resistant, but not insulin-deficient, mice
Author: Jelinic, M.
Kahlberg, N.
Leo, C.H.
Ng, H.H.
Rosli, S.
Deo, M.
Li, M.
Finlayson, S.
Walsh, J.
Parry, L.J.
Ritchie, R.H.
Qin, C.X.
Citation: British Journal of Pharmacology, 2020; 177(7):1677-1691
Publisher: Wiley
Issue Date: 2020
ISSN: 0007-1188
Statement of
Maria Jelinic, Nicola Kahlberg, Chen Huei Leo, Hooi Hooi Ng, Sarah Rosli, Minh Deo, Mandy Li, Siobhan Finlayson, Jesse Walsh, Laura J. Parry, Rebecca H. Ritchie, Cheng Xue Qin
Abstract: Background and purpose: Arterial stiffness, a characteristic feature of diabetes, increases the risk of cardiovascular complications. Potential mechanisms that promote arterial stiffness in diabetes include oxidative stress, glycation and inflammation. The anti-inflammatory protein annexin-A1 has cardioprotective properties, particularly in the context of ischaemia. However, the role of endogenous annexin- A1 in the vasculature in both normal physiology and pathophysiology remains largely unknown. Hence, this study investigated the role of endogenous annexin-A1 in diabetes-induced remodelling of mouse mesenteric vasculature. Experimental approach: Insulin-resistance was induced in male mice (AnxA1+/+ and AnxA1-/-) with the combination of streptozotocin (55mg/kg i.p. x 3 days) with high fat diet (42% energy from fat) or citrate vehicle with normal chow diet (20-weeks). Insulin-deficiency was induced in a separate cohort of mice using a higher total streptozocin dose (55mg/kg i.p. x 5 days) on chow diet (16-weeks). At study endpoint, mesenteric artery passive mechanics were assessed by pressure myography. Key results: Insulin-resistance induced significant outward remodelling but had no impact on passive stiffness. Interestingly, vascular stiffness was significantly increased in AnxA1-/- mice when subjected to insulin-resistance. In contrast, insulindeficiency induced outward remodelling and increased volume compliance in mesenteric arteries, regardless of genotype. In addition, the annexin-A1 / formyl peptide receptor axis is upregulated in both insulin-resistant and insulin-deficient mice. Conclusion and implications: Our study provided the first evidence that endogenous AnxA1 may play an important vasoprotective role in the context of insulin-resistance. AnxA1-based therapies may provide additional benefits over traditional antiinflammatory strategies for reducing vascular injury in diabetes.
Keywords: Animals
Insulin Resistance
Annexin A1
Receptors, Formyl Peptide
Rights: © 2019 The British Pharmacological Society
DOI: 10.1111/bph.14927
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