Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/124072
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Screening for frailty in older patients with early-stage solid tumors: a prospective longitudinal evaluation of three different geriatric tools
Author: Biganzoli, L.
Mislang, A.
DI Donato, S.
Becheri, D.
Biagioni, C.
Vitale, S.
Sanna, G.
Zafarana, E.
Gabellini, S.
Del Monte, F.
Mori, E.
Pozzessere, D.
Brunello, A.
Luciani, A.
Laera, L.
Boni, L.
DI Leo, A.
Mottino, G.
Citation: Journals of Gerontology, Series A, 2017; 72(7):922-928
Publisher: Oxford University Press (OUP)
Issue Date: 2017
ISSN: 1079-5006
1758-535X
Statement of
Responsibility: 
Laura Biganzoli, Anna Rachelle Mislang, Samantha Di Donato, Dimitri Becheri, Chiara Biagioni, Stefania Vitale, Giuseppina Sanna, Elena Zafarana, Stefano Gabellini, Francesca Del Monte, Elena Mori, Daniele Pozzessere, Antonella Brunello, Andrea Luciani, Letizia Laera, Luca Boni, Angelo Di Leo, and Giuseppe Mottino
Abstract: Background: Frailty increases the risk of adverse health outcomes and/or dying when exposed to a stressor, and routine frailty assessment is recommended to guide treatment decision. The Balducci frailty criteria (BFC) and Fried frailty criteria (FFC) are commonly used, but these are time consuming. Vulnerable Elders Survey-13 (VES-13) score of ≥7, a simple and resource conserving function-based scoring system, may be used instead. This prospective study evaluates the performance of VES-13 in parallel with BFC and FFC, to identify frailty in elderly patients with early-stage cancer. Methods: Patients aged ≥70 years with early-stage solid tumors were classified as frail/nonfrail based on BFC (≥1 criteria), FFC (≥3 criteria), and VES-13 (score ≥ 7). All patients were assessed for functional decline and death. Results: We evaluated 185 patients. FFC had a 17% frailty rate, whereas BFC and VES-13 both had 25%, with poor concordance seen between the three geriatric tools. FFC (hazard ratio = 1.99, p = .003) and VES-13 (hazard ratio = 2.81, p < .001) strongly discriminated for functional decline, whereas BFC (hazard ratio = 3.29, p < .001) had the highest discriminatory rate for deaths. BFC and VES-13 remained prognostic for overall survival in multivariate analysis correcting for age, tumor type, stage, and systemic treatment. Conclusions: A VES-13 score of ≥7 is a valuable discriminating tool for predicting functional decline or death and can be used as a frailtyscreening tool among older cancer patients in centers with limited resources to conduct a comprehensive geriatric assessment.
Keywords: Frailty; Vulnerable Elders Survey-13; Balducci frailty criteria; Fried frailty criteria; Cancers
Description: Advance Access publication February 2, 2017
Rights: © The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.
RMID: 0030086434
DOI: 10.1093/gerona/glw234
Appears in Collections:Medicine publications

Files in This Item:
File Description SizeFormat 
hdl_124072.pdfAccepted version459.98 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.