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Type: Journal article
Title: Meningococcal B vaccine and meningococcal carriage in adolescents in Australia
Author: Marshall, H.S.
McMillan, M.
Koehler, A.P.
Lawrence, A.
Sullivan, T.R.
MacLennan, J.M.
Maiden, M.C.J.
Ladhani, S.N.
Ramsay, M.E.
Trotter, C.
Borrow, R.
Finn, A.
Kahler, C.M.
Whelan, J.
Vadivelu, K.
Richmond, P.
Citation: New England Journal of Medicine, 2020; 382(4):318-327
Publisher: Massachusetts Medical Society
Issue Date: 2020
ISSN: 0028-4793
Statement of
Helen S. Marshall, Mark McMillan, Ann P. Koehler, Andrew Lawrence, Thomas R. Sullivan ... et al.
Abstract: BACKGROUND:The meningococcal group B vaccine 4CMenB is a new, recombinant protein-based vaccine that is licensed to protect against invasive group B meningococcal disease. However, its role in preventing transmission and, therefore, inducing population (herd) protection is uncertain. METHODS:We used cluster randomization to assign, according to school, students in years 10 to 12 (age, 15 to 18 years) in South Australia to receive 4CMenB vaccination either at baseline (intervention) or at 12 months (control). The primary outcome was oropharyngeal carriage of disease-causing Neisseria meningitidis (group A, B, C, W, X, or Y) in students in years 10 and 11, as identified by polymerase-chain-reaction assays for PorA (encoding porin protein A) and N. meningitidis genogroups. Secondary outcomes included carriage prevalence and acquisition of all N. meningitidis and individual disease-causing genogroups. Risk factors for carriage were assessed at baseline. RESULTS:A total of 237 schools participated. During April through June 2017, a total of 24,269 students in years 10 and 11 and 10,220 students in year 12 were enrolled. At 12 months, there was no difference in the prevalence of carriage of disease-causing N. meningitidis between the vaccination group (2.55%; 326 of 12,746) and the control group (2.52%; 291 of 11,523) (adjusted odds ratio, 1.02; 95% confidence interval [CI], 0.80 to 1.31; P = 0.85). There were no significant differences in the secondary carriage outcomes. At baseline, the risk factors for carriage of disease-causing N. meningitidis included later year of schooling (adjusted odds ratio for year 12 vs. year 10, 2.75; 95% CI, 2.03 to 3.73), current upper respiratory tract infection (adjusted odds ratio, 1.35; 95% CI, 1.12 to 1.63), cigarette smoking (adjusted odds ratio, 1.91; 95% CI, 1.29 to 2.83), water-pipe smoking (adjusted odds ratio, 1.82; 95% CI, 1.30 to 2.54), attending pubs or clubs (adjusted odds ratio, 1.54; 95% CI, 1.28 to 1.86), and intimate kissing (adjusted odds ratio, 1.65; 95% CI, 1.33 to 2.05). No vaccine safety concerns were identified. CONCLUSIONS:Among Australian adolescents, the 4CMenB vaccine had no discernible effect on the carriage of disease-causing meningococci, including group B. (Funded by GlaxoSmithKline; number, NCT03089086.).
Keywords: Humans
Neisseria meningitidis
Neisseria meningitidis, Serogroup B
Meningococcal Infections
Meningococcal Vaccines
Odds Ratio
Risk Factors
Single-Blind Method
Carrier State
Rights: Copyright © 2020, Massachusetts Medical Society. All rights reserved.
DOI: 10.1056/nejmoa1900236
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