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Type: Journal article
Title: NAD⁺ repletion rescues female fertility during reproductive aging
Other Titles: NAD(+) repletion rescues female fertility during reproductive aging
Author: Bertoldo, M.J.
Listijono, D.R.
Ho, W.H.J.
Riepsamen, A.H.
Goss, D.M.
Richani, D.
Jin, X.L.
Mahbub, S.
Campbell, J.M.
Habibalahi, A.
Loh, W.G.N.
Youngson, N.A.
Maniam, J.
Wong, A.S.A.
Selesniemi, K.
Bustamante, S.
Li, C.
Zhao, Y.
Marinova, M.B.
Kim, L.J.
et al.
Citation: Cell Reports, 2020; 30(6):1670-1681.e7
Publisher: Elsevier
Issue Date: 2020
ISSN: 2211-1247
Statement of
Yoshiaki Tanaka, Bilal Cakir, Yangfei Xiang, Gareth J. Sullivan, In-Hyun Park
Abstract: Reproductive aging in female mammals is an irreversible process associated with declining oocyte quality, which is the rate-limiting factor to fertility. Here, we show that this loss of oocyte quality with age accompanies declining levels of the prominent metabolic cofactor nicotinamide adenine dinucleotide (NAD+). Treatment with the NAD+ metabolic precursor nicotinamide mononucleotide (NMN) rejuvenates oocyte quality in aged animals, leading to restoration in fertility, and this can be recapitulated by transgenic overexpression of the NAD+-dependent deacylase SIRT2, though deletion of this enzyme does not impair oocyte quality. These benefits of NMN extend to the developing embryo, where supplementation reverses the adverse effect of maternal age on developmental milestones. These findings suggest that late-life restoration of NAD+ levels represents an opportunity to rescue female reproductive function in mammals.
Keywords: Embryo development
Description: Published:February 11, 2020
Rights: © 2020 The Author(s). This is an open access article under the CC BY-NC-ND license (
DOI: 10.1016/j.celrep.2020.01.058
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