Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/124212
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Type: Journal article
Title: GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI
Author: Alves, A.C.
De Silva, N.M.G.
Karhunen, V.
Sovio, U.
Das, S.
Rob Taal, H.
Warrington, N.M.
Lewin, A.M.
Kaakinen, M.
Cousminer, D.L.
Thiering, E.
Timpson, N.J.
Bond, T.A.
Lowry, E.
Brown, C.D.
Estivill, X.
Lindi, V.
Bradfield, J.P.
Geller, F.
Speed, D.
et al.
Citation: Science Advances, 2019; 5(9):1-17
Publisher: American Association for the Advancement of Science
Issue Date: 2019
ISSN: 2375-2548
2375-2548
Statement of
Responsibility: 
Alexessander Couto Alves ... Debbie A. Lawlor ... Lyle J. Palmer ... et al. ... [The Early Growth Genetics (EGG) Consortium]
Abstract: Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult body mass index (BMI), with variants associated with adult BMI acting as early as 4 to 6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies.
Keywords: BIOS Consortium
Early Growth Genetics (EGG) Consortium
Humans
Genetic Predisposition to Disease
Intracellular Signaling Peptides and Proteins
Adaptor Proteins, Signal Transducing
Body Mass Index
Longitudinal Studies
Genomics
Quantitative Trait, Heritable
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Adult
Child
Infant
Female
Male
Receptors, Leptin
Genome-Wide Association Study
Genetic Association Studies
Growth Charts
Pharmacogenomic Variants
Rights: Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI: 10.1126/sciadv.aaw3095
Grant ID: http://purl.org/au-research/grants/nhmrc/403981
http://purl.org/au-research/grants/nhmrc/003209
Appears in Collections:Aurora harvest 4
Medicine publications

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