Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/124250
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Type: Journal article
Title: Quality of life assessment in esophageal atresia patients: a systematic review focusing on long-gap esophageal atresia
Author: Tan Tanny, S.P.
Comella, A.
Hutson, J.M.
Omari, T.I.
Teague, W.J.
King, S.K.
Citation: Journal of Pediatric Surgery, 2019; 54(12):2473-2478
Publisher: Elsevier
Issue Date: 2019
ISSN: 0022-3468
1531-5037
Statement of
Responsibility: 
Sharman P. Tan Tanny, Assia Comella, John M. Hutson, Taher I. Omari, Warwick J. Teague, Sebastian K. King
Abstract: Background: Children born with esophageal atresia (EA) have inherent abnormalities in esophageal motility which may impact upon patient and family Quality of Life (QoL). Currently, paucity of data exists for long-term outcomes of long-gap EA. We aimed to: (1) summarize QoL tools reported in the literature, focusing upon studies involving long-gap EA patients, and (2) compare QoL for long-gap versus non-long-gap EA patients. Method: We performed a systematic review of Cochrane Register of Controlled Trials, PubMed, EMBASE, and Ovid databases (January 1980-May 2018) in accordance with the PRISMA protocol. Result: Six studies were identified (536 patients total), and 419/536 (78%) patients completed QoL assessment. Response rates ranged from 29% to 100%. Median study size was 86 (range 8-159). Esophageal atresia type was described in 477 patients, and 74/477 (16%) were long-gap. Common assessment tools were Gastrointestinal Quality of Life Index and 36-Item Short-Form Health Survey. Compared with healthy individuals, long-gap EA patients suffered more gastrointestinal symptoms. There were no significant differences in QoL outcomes between long-gap and non-long-gap EA patients. Conclusion: Current literature suggests no significant difference in QoL outcomes between long-gap and non-long-gap EA patients. However, due to questionnaire variability and range of response rates, the data should be interpreted with care. Level of Evidence: Level II.
Keywords: Esophageal atresia; long-gap; quality of life; systematic review
Rights: Crown Copyright © 2019 Published by Elsevier Inc. All rights reserved.
DOI: 10.1016/j.jpedsurg.2019.08.040
Grant ID: http://purl.org/au-research/grants/nhmrc/1168142
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