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Type: Journal article
Title: Stem cell directed therapies for osteoarthritis: the promise and the practice: concise review
Author: Ng, J.
Little, C.B.
Woods, S.
Whittle, S.
Lee, F.Y.
Gronthos, S.
Mukherjee, S.
Hunter, D.J.
Worthley, D.L.
Citation: Stem Cells Translational Medicine, 2019; 38(4):477-486
Publisher: Wiley
Issue Date: 2019
ISSN: 2157-6564
Statement of
Jia Ng ... Susan Woods, Samuel Whittle ... Stan Gronthos .... David J. Hunter, Daniel L. Worthley ... et al.
Abstract: Osteoarthritis (OA) is a disease of an entire synovial joint characterized by clinical symptoms and distortion of joint tissues including cartilage, muscles, ligaments and bone. While OA is a disease of all joint tissues it is a defined accessible compartment and is thus amenable to topical surgical and regenerative therapies, including stem cells. All tissues arise from stem progenitor cells, and the relative capacity of different cellular compartments, and different individuals, to renew tissues into adulthood may be important in the onset of many different degenerative diseases. OA is driven by both mechanical and inflammatory factors, but how these impacts the proliferation and differentiation of cells into cartilage in vivo is largely unknown. Indeed, our very basic understanding of the physiological cellular kinetics and biology of the stem-progenitor cell unit of the articular cartilage, and how this is influenced by mechanoinflammatory injury, is largely unknown. OA seems, rather deceptively, to be the low-hanging fruit for stem cell therapy. Without the basic understanding of the stem cell and progenitor unit that generate and maintain articular cartilage in vivo, we will continue to waste opportunities to both prevent and manage this disease. In this review, we discuss the biology of chondrogenesis, the stem cell populations that support articular cartilage in health and disease and future opportunities afforded through the translation of basic articular chondrocyte stem cell biology into new clinical therapies. © AlphaMed Press 2019 SIGNIFICANCE STATEMENT: Despite much promise for stem cell-based therapy in osteoarthritis (OA), results have by far fallen short on their potential. Are our current knowledge of the stem cell biology of the articular cartilage reflective of their potential in health and disease? Can we expand on the current understanding of the promise and practice of stem cell therapy for OA? This concise review discuss about the new development in articular stem cell biology as well as the current clinical practice of stem cell-based therapy for OA.
Keywords: articular cartilage; chondrocytes; osteoarthritis; stem cells
Rights: © AlphaMed Press 2019
DOI: 10.1002/stem.3139
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