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Type: Journal article
Title: γ-Aminobutyric acid (GABA) signalling in plants
Other Titles: Gamma-Aminobutyric acid (GABA) signalling in plants
Author: Ramesh, S.
Tyerman, S.
Gilliham, M.
Xu, B.
Citation: Cellular and Molecular Life Sciences, 2017; 74(9):1577-1603
Publisher: Springer (part of Springer Nature)
Issue Date: 2017
ISSN: 1420-682X
Statement of
Sunita A. Ramesh, Stephen D. Tyerman, Matthew Gilliham, Bo Xu
Abstract: The role of γ-aminobutyric acid (GABA) as a signal in animals has been documented for over 60 years. In contrast, evidence that GABA is a signal in plants has only emerged in the last 15 years, and it was not until last year that a mechanism by which this could occur was identified-a plant 'GABA receptor' that inhibits anion passage through the aluminium-activated malate transporter family of proteins (ALMTs). ALMTs are multigenic, expressed in different organs and present on different membranes. We propose GABA regulation of ALMT activity could function as a signal that modulates plant growth, development, and stress response. In this review, we compare and contrast the plant 'GABA receptor' with mammalian GABAA receptors in terms of their molecular identity, predicted topology, mode of action, and signalling roles. We also explore the implications of the discovery that GABA modulates anion flux in plants, its role in signal transduction for the regulation of plant physiology, and predict the possibility that there are other GABA interaction sites in the N termini of ALMT proteins through in silico evolutionary coupling analysis; we also explore the potential interactions between GABA and other signalling molecules.
Keywords: γ-Aminobutyric acid
Aluminium-activated malate transporters
GABAA receptors
GABA metabolism
Carbon–nitrogen balance
Stress response
Description: Published online: 12 November 2016
Rights: © Springer International Publishing 2016
DOI: 10.1007/s00018-016-2415-7
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