Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/124400
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Type: Journal article
Title: Predictors of health-related quality of life in patients with co-morbid diabetes and chronic kidney disease
Author: Zimbudzi, E.
Lo, C.
Ranasinha, S.
Gallagher, M.
Fulcher, G.
Kerr, P.G.
Russell, G.
Teede, H.
Usherwood, T.
Walker, R.
Zoungas, S.
Citation: PLoS One, 2016; 11(12):e0168491-e0168491
Publisher: PLOS
Issue Date: 2016
ISSN: 1932-6203
1932-6203
Editor: Barretti, P.
Statement of
Responsibility: 
Edward Zimbudzi, Clement Lo, Sanjeeva Ranasinha, Martin Gallagher, Gregory Fulcher ... Helena Teede ... et al.
Abstract: People living with diabetes and chronic kidney disease (CKD) experience compromised quality of life. Consequently, it is critical to identify and understand factors influencing their health-related quality of life (HRQoL). This study examined factors associated with HRQoL among patients with diabetes and CKD.A cross sectional study among adults with comorbid diabetes and CKD (eGFR <60 mL/min/1.73m2) recruited from renal and diabetes clinics of four large tertiary referral hospitals in Australia was performed. Each participant completed the Kidney Disease Quality of Life (KDQoL ™ -36) questionnaire, which is comprised of two composite measures of physical and mental health and 3 kidney disease specific subscales with possible scores ranging from 0 to 100 with higher values indicating better HRQoL. Demographic and clinical data were also collected. Regression analyses were performed to determine the relationship between HRQoL and potential predictor factors.A total of 308 patients were studied with a mean age of 66.9 (SD = 11.0) years and 70% were males. Mean scores for the physical composite summary, mental composite summary, symptom/problem list, effects of kidney disease and burden of kidney disease scales were 35.2, 47.0, 73.8, 72.5 and 59.8 respectively. Younger age was associated with lower scores in all subscales except for the physical composite summary. Female gender, obese or normal weight rather than overweight, and smoking were all associated with lower scores in one or more subscales. Scores were progressively lower with more advanced stage of CKD (p<0.05) in all subscales except for the mental composite summary.In patients with diabetes and CKD, younger age was associated with lower scores in all HRQoL subscales except the physical composite summary and female gender, obese or normal weight and more advanced stages of CKD were associated with lower scores in one or more subscales. Identifying these factors will inform the timely implementation of interventions to improve the quality of life of these patients.
Keywords: Renal Insufficiency, Chronic
Rights: © 2016 Zimbudzi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI: 10.1371/journal.pone.0168491
Grant ID: http://purl.org/au-research/grants/nhmrc/1055175
Published version: http://dx.doi.org/10.1371/journal.pone.0168491
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