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Type: Journal article
Title: Acupuncture for menopausal hot flashes: a randomized trial
Author: Ee, C.
Xue, C.
Chondros, P.
Myers, S.
French, S.
Teede, H.
Pirotta, M.
Citation: Annals of Internal Medicine, 2016; 164(3):146-154
Publisher: American College of Physicians
Issue Date: 2016
ISSN: 0003-4819
Statement of
Carolyn Ee, Charlie Xue, Patty Chondros, Stephen P. Myers, Simon D. French, Helena Teede, Marie Pirotta
Abstract: Hot flashes (HFs) affect up to 75% of menopausal women and pose a considerable health and financial burden. Evidence of acupuncture efficacy as an HF treatment is conflicting.To assess the efficacy of Chinese medicine acupuncture against sham acupuncture for menopausal HFs.Stratified, blind (participants, outcome assessors, and investigators, but not treating acupuncturists), parallel, randomized, sham-controlled trial with equal allocation. (Australia New Zealand Clinical Trials Registry: ACTRN12611000393954).Community in Australia.Women older than 40 years in the late menopausal transition or postmenopause with at least 7 moderate HFs daily, meeting criteria for Chinese medicine diagnosis of kidney yin deficiency.10 treatments over 8 weeks of either standardized Chinese medicine needle acupuncture designed to treat kidney yin deficiency or noninsertive sham acupuncture.The primary outcome was HF score at the end of treatment. Secondary outcomes included quality of life, anxiety, depression, and adverse events. Participants were assessed at 4 weeks, the end of treatment, and then 3 and 6 months after the end of treatment. Intention-to-treat analysis was conducted with linear mixed-effects models.327 women were randomly assigned to acupuncture (n = 163) or sham acupuncture (n = 164). At the end of treatment, 16% of participants in the acupuncture group and 13% in the sham group were lost to follow-up. Mean HF scores at the end of treatment were 15.36 in the acupuncture group and 15.04 in the sham group (mean difference, 0.33 [95% CI, -1.87 to 2.52]; P = 0.77). No serious adverse events were reported.Participants were predominantly Caucasian and did not have breast cancer or surgical menopause.Chinese medicine acupuncture was not superior to noninsertive sham acupuncture for women with moderately severe menopausal HFs.National Health and Medical Research Council.
Keywords: Double-Blind Method
Rights: © 2016 American College of Physicians
DOI: 10.7326/M15-1380
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